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EARLY EFFECTS OF PENICILLIN TREATMENT OF DEMENTIA PARALYTICA: A Clinical and Psychologic Study

EARLY EFFECTS OF PENICILLIN TREATMENT OF DEMENTIA PARALYTICA: A Clinical and Psychologic Study Abstract The introduction of penicillin has caused a renewed interest in the treatment of early1 and late2 syphilis. In this paper an account is given of the course of early dementia paralytica in a man aged 31 who at no time was subjected to any other form of therapy. Treatment with penicillin appeared to produce a remission. Psychologic examinations made before and after treatment confirmed the clinical impression of remission and permitted a roughly quantitative estimate of the degree of improvement. Since serologic reversal is often minimal or absent when penicillin alone is used in the treatment of late syphilis, it is suggested that psychologic examinations, repeated at stated intervals, may provide an early indication for repetition of treatment. The clinical methods used in this study were the standard physical, neurologic and serologic tests and examination of the cerebrospinal fluid. The psychologic methods utilized were the Wechsler-Bellevue Adult Scale References 1. Mahoney, J. F.; Arnold, R. C., and Harris, A.: Penicillin Treatment of Early Syphilis: A Preliminary Report , Ven. Dis. Inform. 24:355-357 ( (Dec.) ) 1943. 2. Mahoney, J. F.; Arnold, R. C.; Sterner, B. L.; Harris, A., and Zwally, M. R.: Penicillin Treatment of Early Syphilis , J. A. M. A. 126:63-67 ( (Sept. 9) ) 1944.Crossref 3. Moore, J. E.; Mahoney, J. F.; Schwartz, W. H.; Sternberg, T. H., and Wood, W. B.: The Treatment of Early Syphilis with Penicillin , J. A. M. A. 126:67-73 ( (Sept. 9) ) 1944.Crossref 4. Stokes, J. H.; Sternberg, T. H.; Schwartz, W. H.; Mahoney, J. F.; Moore, J. E., and Wood, W. B., Jr.: The Action of Penicillin in Late Syphilis , J. A. M. A. 126:73-80 ( (Sept. 9) ) 1944.Crossref 5. Wechsler, D.: The Measurement of Adult Intelligence , ed. 3, Baltimore, Williams & Wilkins Company, 1944. 6. Rorschach, H.: Psychodiagnostik: Methodik und Ergebnisse eines wahrnehmungsdiagnostischen Experiments (Deutenlassen von Zufallsformen) , ed. 4, Bern, Hans Huber, 1941. 7. Klopfer, B., and Kelley, D. M.: The Rorschach Technique , New York, World Book Company, 1942. 8. Oppenheimer, E., and Speijer, N.: Results of Rorschach Test in Case of General Paralysis Before and After Malarial Cure , Psychiat. en neurol. bl. 41:386-391 ( (May-June) ) 1937. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

EARLY EFFECTS OF PENICILLIN TREATMENT OF DEMENTIA PARALYTICA: A Clinical and Psychologic Study

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Publisher
American Medical Association
Copyright
Copyright © 1946 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1946.02300140097006
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Abstract

Abstract The introduction of penicillin has caused a renewed interest in the treatment of early1 and late2 syphilis. In this paper an account is given of the course of early dementia paralytica in a man aged 31 who at no time was subjected to any other form of therapy. Treatment with penicillin appeared to produce a remission. Psychologic examinations made before and after treatment confirmed the clinical impression of remission and permitted a roughly quantitative estimate of the degree of improvement. Since serologic reversal is often minimal or absent when penicillin alone is used in the treatment of late syphilis, it is suggested that psychologic examinations, repeated at stated intervals, may provide an early indication for repetition of treatment. The clinical methods used in this study were the standard physical, neurologic and serologic tests and examination of the cerebrospinal fluid. The psychologic methods utilized were the Wechsler-Bellevue Adult Scale References 1. Mahoney, J. F.; Arnold, R. C., and Harris, A.: Penicillin Treatment of Early Syphilis: A Preliminary Report , Ven. Dis. Inform. 24:355-357 ( (Dec.) ) 1943. 2. Mahoney, J. F.; Arnold, R. C.; Sterner, B. L.; Harris, A., and Zwally, M. R.: Penicillin Treatment of Early Syphilis , J. A. M. A. 126:63-67 ( (Sept. 9) ) 1944.Crossref 3. Moore, J. E.; Mahoney, J. F.; Schwartz, W. H.; Sternberg, T. H., and Wood, W. B.: The Treatment of Early Syphilis with Penicillin , J. A. M. A. 126:67-73 ( (Sept. 9) ) 1944.Crossref 4. Stokes, J. H.; Sternberg, T. H.; Schwartz, W. H.; Mahoney, J. F.; Moore, J. E., and Wood, W. B., Jr.: The Action of Penicillin in Late Syphilis , J. A. M. A. 126:73-80 ( (Sept. 9) ) 1944.Crossref 5. Wechsler, D.: The Measurement of Adult Intelligence , ed. 3, Baltimore, Williams & Wilkins Company, 1944. 6. Rorschach, H.: Psychodiagnostik: Methodik und Ergebnisse eines wahrnehmungsdiagnostischen Experiments (Deutenlassen von Zufallsformen) , ed. 4, Bern, Hans Huber, 1941. 7. Klopfer, B., and Kelley, D. M.: The Rorschach Technique , New York, World Book Company, 1942. 8. Oppenheimer, E., and Speijer, N.: Results of Rorschach Test in Case of General Paralysis Before and After Malarial Cure , Psychiat. en neurol. bl. 41:386-391 ( (May-June) ) 1937.

Journal

Archives of Neurology & Psychiatry – American Medical Association

Published: Mar 1, 1946

References

  • Penicillin Treatment of Early Syphilis: A Preliminary Report
    Mahoney , J. F.; Arnold, R. C., and Harris, A.
  • Penicillin Treatment of Early Syphilis
    Mahoney , J. F.; Arnold, R. C.; Sterner, B. L.; Harris, A., and Zwally, M. R.
  • The Treatment of Early Syphilis with Penicillin
    Moore , J. E.; Mahoney, J. F.; Schwartz, W. H.; Sternberg, T. H., and Wood, W. B.
  • The Action of Penicillin in Late Syphilis
    Stokes , J. H.; Sternberg, T. H.; Schwartz, W. H.; Mahoney, J. F.; Moore, J. E., and Wood, W. B., Jr.
  • The Measurement of Adult Intelligence
    Wechsler , D.
  • Psychodiagnostik: Methodik und Ergebnisse eines wahrnehmungsdiagnostischen Experiments (Deutenlassen von Zufallsformen)
    Rorschach , H.
  • The Rorschach Technique
    Klopfer , B., and Kelley, D. M.
  • Results of Rorschach Test in Case of General Paralysis Before and After Malarial Cure
    Oppenheimer , E., and Speijer, N.