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G. Odell (1959)
Studies in kernicterus. I. The protein binding of bilirubin.The Journal of clinical investigation, 38 5
S. Blondheim (1955)
The relationship between the albumin concentration of serum and its dye-binding capacity.The Journal of laboratory and clinical medicine, 45 5
C. Huggins , E. V. Jensen, M. A. Player (1949)
The Binding of Phenolsulfonephthalcin by Serum and by Albumin Isolated from Serum in CancerCancer Res., 9
A. Sass-Kortsak (1961)
Kernicterus
I. Klotz (1946)
Spectrophotometric investigations of the interactions of proteins with organic anions.Journal of the American Chemical Society, 68 11
G. Miller, M. Davis, A. King, C. Huggins (1951)
Serum proteins in pregnancy; thermal coagulation and the binding of anions.The Journal of laboratory and clinical medicine, 37 4
W. J. Waters (1960)
The Origin of Jaundice in the NewbornAmer. J. Dis. Child., 100
U. Westphal, J. Stets, S. Priest (1953)
Influence of fatty acids and related anions on the azorubin-binding capacity of serum albumin.Archives of biochemistry and biophysics, 43 2
W. Waters (1958)
The prevention of bilirubin encephalopathy.The Journal of pediatrics, 52 5
U. Westphal, P. Gedigk (1951)
Azorubin-Binding Capacity of Normal and Pathological Sera.∗Proceedings of the Society for Experimental Biology and Medicine, 76
I. Klotz, H. Triwush, F. Walker (1948)
The binding of organic ions by proteins; competition phenomena and denaturation effects.Journal of the American Chemical Society, 70 9
W. Kitchen, V. Krieger, Margery Smith (1960)
Human albumin in exchange transfusionThe Journal of Pediatrics, 57
Gerard Odell (1959)
The dissociation of bilirubin from albumin and its clinical implications.The Journal of pediatrics, 55
N. Martin (1949)
Preparation and properties of serum and plasma proteins; interactions with bilirubin.Journal of the American Chemical Society, 71 4
W. R. Bowen , E. Porter (1959)
The Protective Action of Albumin in Bilirubin Toxicity in Newborn PuppiesA.M.A. J. Dis. Child., 98
Abstract In recent years considerable evidence has been reported in support of the theory that bilirubin is toxic to the newborn brain (bilirubin encephalopathy). It has been further suggested that perhaps free bilirubin, that which is not bound to albumin, is the toxic substance.1 Utilizing this information, studies were done in newborn puppies which suggested a protective action for albumin against bilirubin toxicity.2 It therefore seemed advisable to determine the binding capacity of albumin in the newborn, particularly in the infant with hemolytic disease. A reduction in the capacity of serum albumin to bind anionic dyes has been reported in patients with cancer,3 severe kidney and liver disease, infections,4 and in pregnancy.5 Blondheim6 found that the amount of phenolsulfonphthalein bound by serum was related to the albumin concentration in excess of a critical concentration of 1.5 gm.%. He concluded that dye-binding in diseased states was References 1. Sass-Kortsak, A., editor, Kernicterus , Toronto, University of Toronto Press, 1961. 2. Bowen, W. R.; Porter, E., and Waters, W. J.: The Protective Action of Albumin in Bilirubin Toxicity in Newborn Puppies , A.M.A. J. Dis. Child. 98:568, 1959. 3. Huggins, C.; Jensen, E. V.; Player, M. A., and Hospelhorn, V. D.: The Binding of Phenolsulfonephthalcin by Serum and by Albumin Isolated from Serum in Cancer , Cancer Res. 9:753, 1949. 4. Westphal, U., and Gedigk, P.: Azorubin-Binding Capacity of Normal and Pathological Sera , Proc. Soc. Exp. Biol. Med. 76:838, 1951.Crossref 5. Miller, G. H.; Davis, M. E.; King, A. G., and Huggins, C. B.: Serum Proteins in Pregnancy: Thermal Coagulation and the Binding of Anions , J. Lab. Clin. Med. 37:538, 1951. 6. Blondheim, S. H.: The Relationship Between the Albumin Concentration of Serum and Its Dye-Binding Capacity , J. Lab. Clin. Med. 45:740, 1955. 7. Waters, W. J.: The Prevention of Bilirubin Encephalopathy , J. Pediat. 52:559, 1958.Crossref 8. Klotz, I. M.: Spectrophotometric Investigations of the Interactions of Proteins with Organic Anions , J. Amer. Chem. Soc. 68:2299, 1946.Crossref 9. Klotz, I. M.; Triwush, H., and Walker, F. M.: The Binding of Organic Ions by Proteins: Competition Phenomena and Denaturation Effects , J. Amer. Chem. Soc. 70:2935, 1948.Crossref 10. Odell, G. B.: Studies in Kernicterus: 1. The Protein Binding of Bilirubin , J. Clin. Invest. 38: 823, 1959.Crossref 11. Odell, G. B.: The Dissociation of Bilirubin from Albumin and Its Clinical Implications , J. Pediat. 55:268, 1959.Crossref 12. Westphal, U.; Stets, J. F., and Priest, S. G.: Influence of Fatty Acids and Related Anions on the Azorubin-Binding Capacity of Serum Albumin , Arch. Biochem. 43:463, 1953.Crossref 13. Waters, W. J.: The Origin of Jaundice in the Newborn , Amer. J. Dis. Child. 100:785, 1960. 14. Martin, N. H.: Preparation and Properties of Serum and Plasma Proteins: XXI. Interactions with Bilirubin , J. Amer. Chem. Soc. 71:1230, 1949.Crossref 15. Kitchen, W. H.; Krieger, V. I., and Smith, M. A.: Human Albumin in Exchange Transfusion , J. Pediat. 57:876, 1960.Crossref
American Journal of Diseases of Children – American Medical Association
Published: Dec 1, 1961
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