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Abstract The cause of peptic ulcer is unknown, and, unlike many diseases, even its control on empirical grounds is unsatisfactory. The amount of clinical and experimental work that has been done on the subject is enormous, and, as may be expected, there is a wide difference of opinion concerning its many phases. It is impossible to review all of the prevailing ideas adequately in this short paper; however, a brief summary of current opinion is important in order to lay the foundation for successful study. From the standpoint of the clinician and the experimental surgeon, three theories have been advanced as to the cause of peptic ulcer: first, the physiologic or secretory theory; second, the local anatomic or mechanical theory, and third, the general constitutional or systemic theory. The secretory theory, or the theory based on the digestive action of the gastric juice and the normal resisting powers of gastric and References 1. Mann, F. C. and Williamson, C. S.: The Experimental Production of Peptic Ulcer , Ann. Surg. 77:409, 1923.Crossref 2. Matthews, W. B., and Dragstedt, L. R.: The Etiology of Gastric and Duodenal Ulcer , Surg., Gynec. & Obst. 55:265 ( (Sept.) ) 1932. 3. Berman, J. K.: Critical Evaluation and Present Status of the Theory of Chronic Focal Infection , J. Indiana M. A. 24:665, 1931. 4. Cushing, Harvey: Peptic Ulcers and Interbrain (Balfour Lecture) , Surg., Gynec. & Obst. 55:1 ( (July) ) 1932. 5. Pende, Nicola: Constitutional Inadequacies , Philadelphia, Lea & Febiger, 1928. 6. Draper, George: Disease and the Man , New York, The Macmillan Company, 1930. 7. Gianturco, Cesare: Experimental Studies on the Pyloric Mechanism , Proc. Staff Meet., Mayo Clin. 8:784 ( (Dec. 27) ) 1933. 8. Van Liere, Edward J., and Crisler, George: Proc. Soc. Exper. Biol. & Med. 31:85, 1933. 9. Florey, H. W., and Harding, H. E.: The Functions of Brunner's Glands and the Pyloric End of the Stomach , J. Path. & Bact. 37:431, 1933. 10. Murray, Margaret M.: The Small Intestine and Gastric Secretion, with Special Reference to Brunner's Glands , J. Physiol. 69:48, 1930. 11. Van Wagoner, F. H., and Churchill, T. P.: Production of Gastric and Duodenal Ulcers in Experimental Cinchophen Poisoning: Preliminary Report , J. A. M. A. 99:1859 ( (Nov. 26) ) 1932 12. Production of Gastric and Duodenal Ulcers in Experimental Cinchophen Poisoning in Dogs , Arch. Path. 14:860 ( (Dec.) ) 1932. 13. Hurst, A. F.: The Unity of Gastric Disorders , Brit. M. J. 2:89, 1933. 14. Gatch, W. D.: Personal communication to the author. 15. This procedure has been successfully used in man since this article was submitted for publication. A subsequent report will be published after sufficient time has elapsed for proper evaluation of the results of the operation.
Archives of Surgery – American Medical Association
Published: Jul 1, 1936
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