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DRUGS RECENTLY INTRODUCED FOR HYPERTENSION

DRUGS RECENTLY INTRODUCED FOR HYPERTENSION During the last five years several drugs have been introduced for the treatment of hypertension. Of these, hexamethonium, pentolinium tartrate (Ansolysen), and Ecolid [4, 5, 6, 7-tetrachloro-2-(2-dimethylaminoethyl) isoindoline dimethochloride], which was known experimentally as Su 3088, are orally active agents that reduce blood pressure by blocking or suppressing cholinergic nerve transmission through the sympathetic and parasympathetic ganglions. Hydralazine (Apresoline) hydrochloride has a moderate adrenolytic or sympatholytic action. There is some evidence that it increases renal blood flow, depresses the midbrain, or neutralizes certain humoral vasopressor substances. Alkavervir (Veriloid) and protoveratrines A and B (Veralba), alkaloids of Veratrum viride and Veratrum album, respectively, induce dilatation of arterioles by acting on vasomotor centers or influencing the receptors of the buffer nerves. The Veratrum drugs slow the heart rate and in larger doses cause nausea and then vomiting and salivation. Rauwolfia serpentina, its purified fraction, alseroxylon, or its crystalline alkaloid, reserpine, have a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

DRUGS RECENTLY INTRODUCED FOR HYPERTENSION

JAMA , Volume 158 (5) – Jun 4, 1955

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1955.02960050001001
Publisher site
See Article on Publisher Site

Abstract

During the last five years several drugs have been introduced for the treatment of hypertension. Of these, hexamethonium, pentolinium tartrate (Ansolysen), and Ecolid [4, 5, 6, 7-tetrachloro-2-(2-dimethylaminoethyl) isoindoline dimethochloride], which was known experimentally as Su 3088, are orally active agents that reduce blood pressure by blocking or suppressing cholinergic nerve transmission through the sympathetic and parasympathetic ganglions. Hydralazine (Apresoline) hydrochloride has a moderate adrenolytic or sympatholytic action. There is some evidence that it increases renal blood flow, depresses the midbrain, or neutralizes certain humoral vasopressor substances. Alkavervir (Veriloid) and protoveratrines A and B (Veralba), alkaloids of Veratrum viride and Veratrum album, respectively, induce dilatation of arterioles by acting on vasomotor centers or influencing the receptors of the buffer nerves. The Veratrum drugs slow the heart rate and in larger doses cause nausea and then vomiting and salivation. Rauwolfia serpentina, its purified fraction, alseroxylon, or its crystalline alkaloid, reserpine, have a

Journal

JAMAAmerican Medical Association

Published: Jun 4, 1955

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