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Drugs for Urinary Tract Infections

Drugs for Urinary Tract Infections Clinical Review & Education The Medical Letter on Drugs and Therapeutics The most recent guidelines from the Infectious Diseases Society Table 3. Some Adverse Effects of America (IDSA) and its European counterpart on the choice of Drug Adverse Effects antimicrobials for treatment of uncomplicated urinary tract infec- Trimethoprim/ Nausea, vomiting, anorexia, hypersensitivity tions (UTIs) in non-pregnant women focus on the unnecessary sulfamethoxazole reactions (rash, urticaria, photosensitivity, use of fluoroquinolones to treat uropathogens that are increas- fever), hemolysis in G6PD deficiency, hemato- 1 logic abnormalities, C. difficile-associated ingly becoming resistant to them. Resistance of Escherichia coli diarrhea (CDAD), hyperkalemia to ciprofloxacin in the US has increased from 3% in 2000 to 17.1% Nitrofurantoin GI disturbance, headache, allergic reactions monohydrate/ (including pulmonary infiltrates), lupus-like in 2010. macrocrystals syndrome, hematologic abnormalities, hemo- lytic anemia, peripheral neuropathy, sometimes severe, interstitial pneumonitis and pulmonary Acute Uncomplicated Cystitis fibrosis Fluoroquinolones such as ciprofloxacin or levofloxacin should not be Fosfomycin tromethamine Diarrhea, nausea, headache, vaginitis, dizziness, abdominal pain, asthenia, rash used as first-line agents for empirical treatment of uncomplicated Ciprofloxacin, GI disturbance, headache, dizziness, tremors, cystitis.Beforetheinfectingorganismisknown,thedrugofchoicefor Levofloxacin restlessness, confusion, rash, Candida infections non-pregnantwomenistrimeth- of the pharynx and vagina, eosinophilia, neutro- penia, leukopenia, increased aminotransferases, oprim/sulfamethoxazole (TMP/ http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Drugs for Urinary Tract Infections

JAMA , Volume 311 (8) – Feb 26, 2014

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Publisher
American Medical Association
Copyright
Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2014.972
pmid
24570249
Publisher site
See Article on Publisher Site

Abstract

Clinical Review & Education The Medical Letter on Drugs and Therapeutics The most recent guidelines from the Infectious Diseases Society Table 3. Some Adverse Effects of America (IDSA) and its European counterpart on the choice of Drug Adverse Effects antimicrobials for treatment of uncomplicated urinary tract infec- Trimethoprim/ Nausea, vomiting, anorexia, hypersensitivity tions (UTIs) in non-pregnant women focus on the unnecessary sulfamethoxazole reactions (rash, urticaria, photosensitivity, use of fluoroquinolones to treat uropathogens that are increas- fever), hemolysis in G6PD deficiency, hemato- 1 logic abnormalities, C. difficile-associated ingly becoming resistant to them. Resistance of Escherichia coli diarrhea (CDAD), hyperkalemia to ciprofloxacin in the US has increased from 3% in 2000 to 17.1% Nitrofurantoin GI disturbance, headache, allergic reactions monohydrate/ (including pulmonary infiltrates), lupus-like in 2010. macrocrystals syndrome, hematologic abnormalities, hemo- lytic anemia, peripheral neuropathy, sometimes severe, interstitial pneumonitis and pulmonary Acute Uncomplicated Cystitis fibrosis Fluoroquinolones such as ciprofloxacin or levofloxacin should not be Fosfomycin tromethamine Diarrhea, nausea, headache, vaginitis, dizziness, abdominal pain, asthenia, rash used as first-line agents for empirical treatment of uncomplicated Ciprofloxacin, GI disturbance, headache, dizziness, tremors, cystitis.Beforetheinfectingorganismisknown,thedrugofchoicefor Levofloxacin restlessness, confusion, rash, Candida infections non-pregnantwomenistrimeth- of the pharynx and vagina, eosinophilia, neutro- penia, leukopenia, increased aminotransferases, oprim/sulfamethoxazole (TMP/

Journal

JAMAAmerican Medical Association

Published: Feb 26, 2014

References