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Drug Effects on Survival of Homografts of Skins

Drug Effects on Survival of Homografts of Skins Abstract Many attempts have been made to prolong the survival of homografts by suppressing the reticuloendothelial system of the host with drugs and other agents. A study of the Bagg lymphosarcoma in our laboratory showed that the growth of homografts of this tumor in rats was enhanced when the recipient animals were preconditioned with certain cytotoxic drugs and antimetabolites.4 This study has been extended to determine if these agents affect the survival of homograft of normal skin. The transparent chamber technique was used because it provides an accurate criteria of survival of homografts. Skin is an organ which is very sensitive to the homograft rejection mechanism. Drugs which affect the survival of homografts of skin might have a similar effect upon homografts of other tissues. It is hoped that the simple technique described in this paper might be useful in the selection of drugs for the conditioning of animals for References 1. Algire, G. H.: Microscopic Studies of the Early Growth of a Transplantable Melanoma of the Mouse, Using the Transparent-Chamber Technique , J Nat Cancer Inst 4:13, 1943. 2. Conway, H.; Griffith, B. H.; Shannon, J. E., Jr.; and Findley, A.: Re-Examination of the Transparent Chamber Technique as Applied to the Study of Circulation in Autografts and Homografts of Skin , Plast Reconstr Surg 20:103, 1957.Crossref 3. Edgerton, M. T.; Peterson, H. A.; and Edgerton, P. J.: The Homograft Rejection Mechanism , AMA Arch Surg 74:238, 1957.Crossref 4. Henegar, G. C.; Jackson, E. J.; and Preston, F. W.: Host Conditioning for Homologous Tumor Transplants , Surg Forum 12:165, 1961. 5. Levinson, M. E., and Necheles, H.: Successful Prolongation of Survival of Skin Homografts , Plast Reconstr Surg 17:218, 1956.Crossref 6. Meeker, W. R., Jr.; Condie, R. M.; Good, R. A.; and Varco, R. L.: Alteration of the Homograft Response by Antimetabolites , Ann NY Acad Sci 87:203, 1960.Crossref 7. Schwartz, R., and Dameshek, W.: Drug-Induced Immunological Tolerance , Nature (London) 183:1682, 1959.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1963.01310170126021
Publisher site
See Article on Publisher Site

Abstract

Abstract Many attempts have been made to prolong the survival of homografts by suppressing the reticuloendothelial system of the host with drugs and other agents. A study of the Bagg lymphosarcoma in our laboratory showed that the growth of homografts of this tumor in rats was enhanced when the recipient animals were preconditioned with certain cytotoxic drugs and antimetabolites.4 This study has been extended to determine if these agents affect the survival of homograft of normal skin. The transparent chamber technique was used because it provides an accurate criteria of survival of homografts. Skin is an organ which is very sensitive to the homograft rejection mechanism. Drugs which affect the survival of homografts of skin might have a similar effect upon homografts of other tissues. It is hoped that the simple technique described in this paper might be useful in the selection of drugs for the conditioning of animals for References 1. Algire, G. H.: Microscopic Studies of the Early Growth of a Transplantable Melanoma of the Mouse, Using the Transparent-Chamber Technique , J Nat Cancer Inst 4:13, 1943. 2. Conway, H.; Griffith, B. H.; Shannon, J. E., Jr.; and Findley, A.: Re-Examination of the Transparent Chamber Technique as Applied to the Study of Circulation in Autografts and Homografts of Skin , Plast Reconstr Surg 20:103, 1957.Crossref 3. Edgerton, M. T.; Peterson, H. A.; and Edgerton, P. J.: The Homograft Rejection Mechanism , AMA Arch Surg 74:238, 1957.Crossref 4. Henegar, G. C.; Jackson, E. J.; and Preston, F. W.: Host Conditioning for Homologous Tumor Transplants , Surg Forum 12:165, 1961. 5. Levinson, M. E., and Necheles, H.: Successful Prolongation of Survival of Skin Homografts , Plast Reconstr Surg 17:218, 1956.Crossref 6. Meeker, W. R., Jr.; Condie, R. M.; Good, R. A.; and Varco, R. L.: Alteration of the Homograft Response by Antimetabolites , Ann NY Acad Sci 87:203, 1960.Crossref 7. Schwartz, R., and Dameshek, W.: Drug-Induced Immunological Tolerance , Nature (London) 183:1682, 1959.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Nov 1, 1963

References