Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Drug Effects on Ciliary Muscle and Choroid Preparations in Vitro

Drug Effects on Ciliary Muscle and Choroid Preparations in Vitro Abstract The muscular effects of pharmacological substances on isolated iris preparations have been reported by Wessely,1 Poos,2 and many others. However, similar experiments with isolated ciliary muscle preparations have failed. Poos encountered technical difficulties and did not pursue the matter further. Meesmann3 compared the relatively easy task of obtaining preparations from the isolated iris with the "almost hopeless" endeavor to obtain similar preparations from the ciliary muscle. In a previous report, we briefly mentioned an in vitro method of studying the effects of drugs on the ciliary muscle of the cat, using segments of the ciliary body4 (henceforth referred to as ciliary muscle preparations or ciliary muscle strips). The present investigation attempts to compare drug effects on similar preparations of ciliary muscle and choroid, obtained from several species. The emphasis was placed on the musculature of the cat eye. Monkey and rabbit eyes were included to screen References 1. Wessely, K.: Zur Frage der Existenz eines Dilatator iridis , Ber. Dtsch. Ophthal. Ges. 42:26, 1921. 2. Poos, F.: Zur Frage der sympathischen Innervation des Ziliarmuskels und ihrer Bedeutung für die Akkommodation , Klin. Msbl. Augenheilk. 80: 749, 1928. 3. Meesmann, A.: Experimentelle Untersuchungen über die antagonistische Innervation der Ciliarmuskulatur , Graefe. Arch. Ophthal. 152:335, 1952.Crossref 4. van Alphen, G. W. H. M.: On Emmetropia and Ametropia , Ophthalmologica (Suppl.) 1961. 5. Feldberg, W.: Effects of Ganglion-Blocking Substances on the Small Intestine , J. Physiol. 113: 483, 1951. 6. Monjé, M.: Über pharmakodynamische und klinische Untersuchungen der Akkommodation , Graefe. Arch. Ophthal. 152:357, 1952.Crossref 7. Boeke, J.: Innervationsstudien: III. Die Nervenversorgung des M. ciliaris und des M. sphincter iridis bei Säugern und Vögeln , Z. Mikroskopischanat. Forsch. 33:233, 1933. 8. Ballintine, E. J., and Garner, L. L.: Improvement of the Coefficient of Outflow in Glaucomatous Eyes , Arch. Ophthal. 66:314, 1961.Crossref 9. Thompson, J. W.: Studies on the Responses of the Isolated Nictitating Membrane of the Cat , J. Physiol. 141:46, 1958. 10. Feeney, L., and Hogan, M. J.: Electron Microscopy of the Human Choroid: I. Cells and Supporting Structures , Amer. J. Ophthal. 51:1058, 1961. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Drug Effects on Ciliary Muscle and Choroid Preparations in Vitro

Download PDF
13 pages

Loading next page...
 
/lp/american-medical-association/drug-effects-on-ciliary-muscle-and-choroid-preparations-in-vitro-3v4VY4cvNr
Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1962.00960030085017
Publisher site
See Article on Publisher Site

Abstract

Abstract The muscular effects of pharmacological substances on isolated iris preparations have been reported by Wessely,1 Poos,2 and many others. However, similar experiments with isolated ciliary muscle preparations have failed. Poos encountered technical difficulties and did not pursue the matter further. Meesmann3 compared the relatively easy task of obtaining preparations from the isolated iris with the "almost hopeless" endeavor to obtain similar preparations from the ciliary muscle. In a previous report, we briefly mentioned an in vitro method of studying the effects of drugs on the ciliary muscle of the cat, using segments of the ciliary body4 (henceforth referred to as ciliary muscle preparations or ciliary muscle strips). The present investigation attempts to compare drug effects on similar preparations of ciliary muscle and choroid, obtained from several species. The emphasis was placed on the musculature of the cat eye. Monkey and rabbit eyes were included to screen References 1. Wessely, K.: Zur Frage der Existenz eines Dilatator iridis , Ber. Dtsch. Ophthal. Ges. 42:26, 1921. 2. Poos, F.: Zur Frage der sympathischen Innervation des Ziliarmuskels und ihrer Bedeutung für die Akkommodation , Klin. Msbl. Augenheilk. 80: 749, 1928. 3. Meesmann, A.: Experimentelle Untersuchungen über die antagonistische Innervation der Ciliarmuskulatur , Graefe. Arch. Ophthal. 152:335, 1952.Crossref 4. van Alphen, G. W. H. M.: On Emmetropia and Ametropia , Ophthalmologica (Suppl.) 1961. 5. Feldberg, W.: Effects of Ganglion-Blocking Substances on the Small Intestine , J. Physiol. 113: 483, 1951. 6. Monjé, M.: Über pharmakodynamische und klinische Untersuchungen der Akkommodation , Graefe. Arch. Ophthal. 152:357, 1952.Crossref 7. Boeke, J.: Innervationsstudien: III. Die Nervenversorgung des M. ciliaris und des M. sphincter iridis bei Säugern und Vögeln , Z. Mikroskopischanat. Forsch. 33:233, 1933. 8. Ballintine, E. J., and Garner, L. L.: Improvement of the Coefficient of Outflow in Glaucomatous Eyes , Arch. Ophthal. 66:314, 1961.Crossref 9. Thompson, J. W.: Studies on the Responses of the Isolated Nictitating Membrane of the Cat , J. Physiol. 141:46, 1958. 10. Feeney, L., and Hogan, M. J.: Electron Microscopy of the Human Choroid: I. Cells and Supporting Structures , Amer. J. Ophthal. 51:1058, 1961.

Journal

Archives of Ophthalmology – American Medical Association

Published: Jul 1, 1962

References

  • Zur Frage der Existenz eines Dilatator iridis
    Wessely , K.
  • Zur Frage der sympathischen Innervation des Ziliarmuskels und ihrer Bedeutung für die Akkommodation
    Poos , F.
  • Experimentelle Untersuchungen über die antagonistische Innervation der Ciliarmuskulatur
    Meesmann , A.
  • On Emmetropia and Ametropia
    van Alphen , G. W. H. M.
  • Effects of Ganglion-Blocking Substances on the Small Intestine
    Feldberg , W.
  • Über pharmakodynamische und klinische Untersuchungen der Akkommodation
    Monjé , M.
  • Innervationsstudien: III. Die Nervenversorgung des M. ciliaris und des M. sphincter iridis bei Säugern und Vögeln
    Boeke , J.
  • Improvement of the Coefficient of Outflow in Glaucomatous Eyes
    Ballintine , E. J., and Garner, L. L.
  • Studies on the Responses of the Isolated Nictitating Membrane of the Cat
    Thompson , J. W.
  • Electron Microscopy of the Human Choroid: I. Cells and Supporting Structures
    Feeney , L., and Hogan, M. J.