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Dopamine-Sensitive Adenylyl Cyclase in Human Caudate Nucleus: A Study in Control Subjects and Schizophrenic Patients

Dopamine-Sensitive Adenylyl Cyclase in Human Caudate Nucleus: A Study in Control Subjects and... Abstract Striatal adenylyl cyclase activity from autopsied human brain is selectively stimulated by low concentrations of dopamine. Under the experimental conditions used, norepinephrine was about three times less potent than dopamine. Histamine and serotonin were ineffective. The stimulation by dopamine was competitively inhibited by haloperidol. There was no difference between the basal adenylyl cyclase activity or its level after dopamine stimulation between nine control subjects without a psychiatric history and seven patients with chronic schizophrenia. References 1. Stevens J: An anatomy of schizophrenia? Arch Gen Psychiatry 29:177-189, 1973.Crossref 2. Snyder JM, Banerjee SP, Yamamura HI, et al: Drugs, neurotransmitters and schizophrenia . Science 184:1243-1253, 1974.Crossref 3. Griffith JD, Cavanaugh JH, Held J, et al: Experimental psychosis induced by the administration of d-amphetamine , in Costa E, Garattini S (eds): Amphetamines and Related Compounds . New York, Raven Press, 1969, pp 897-904. 4. Kebabian JW, Petzold G, Greengard P: Dopamine sensitive adenylate cyclase in the caudate nucleus of rat brain and its similarity to the "dopamine receptor . Proc Natl Acad Sci USA 69:2145-2149, 1972.Crossref 5. Clement-Cormier YC, Kebabian JW, Petzold GL, et al: Dopamine-sensitive adenylate cyclase in mammalian brain: A possible site of action of antipsychotic drugs . Proc Natl Acad Sci USA 71:1113-1117, 1974.Crossref 6. Miller RJ, Horn AJ, Iversen LL: The action of neuroleptic drugs on dopamine-stimulated adenosine cyclic 3',5' monophosphate production in rat neostriatum and limbic forebrain . Mol Pharmacol 10:759-766, 1974. 7. Neff NH, Costa E: Effect of tricyclic antidepressants and chlorpromazine on brain catecholamine systhesis, in Garattini S, Duke MN (eds): Proceedings of the First International Symposium on Antidepressant Drugs, series 122. New York, Excerpta Medica, 1966, pp 28-34. 8. Zivkovic B, Guidotti A, Revuelta A, et al: Effect of thioridazine, clozapine, and other antipsychotics on the kinetic state of tyrosine hydroxylase and on the turnover rate of dopamine in striatum and accumbens . J Pharmacol Exp Ther , to be published. 9. Zivkovic B, Guidotti A, Costa E: Effect of neuroleptics on striatal tyrosine hydroxylase: Change in the affinity for the pteridine cofactor . Mol Pharmacol 10:727-735, 1974. 10. Guidotti A, Costa E: A role of nicotinic receptors in the regulation of the adenylate cyclase of adrenal medulla . J Pharmacol Exp Ther 189:665-675, 1974. 11. Lowry OH, Rosebrough NJ, Farr AL, et al: Protein measurement with the folin phenol reagent . J Biol Chem 193:265-275, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Dopamine-Sensitive Adenylyl Cyclase in Human Caudate Nucleus: A Study in Control Subjects and Schizophrenic Patients

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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1975.01760260120010
Publisher site
See Article on Publisher Site

Abstract

Abstract Striatal adenylyl cyclase activity from autopsied human brain is selectively stimulated by low concentrations of dopamine. Under the experimental conditions used, norepinephrine was about three times less potent than dopamine. Histamine and serotonin were ineffective. The stimulation by dopamine was competitively inhibited by haloperidol. There was no difference between the basal adenylyl cyclase activity or its level after dopamine stimulation between nine control subjects without a psychiatric history and seven patients with chronic schizophrenia. References 1. Stevens J: An anatomy of schizophrenia? Arch Gen Psychiatry 29:177-189, 1973.Crossref 2. Snyder JM, Banerjee SP, Yamamura HI, et al: Drugs, neurotransmitters and schizophrenia . Science 184:1243-1253, 1974.Crossref 3. Griffith JD, Cavanaugh JH, Held J, et al: Experimental psychosis induced by the administration of d-amphetamine , in Costa E, Garattini S (eds): Amphetamines and Related Compounds . New York, Raven Press, 1969, pp 897-904. 4. Kebabian JW, Petzold G, Greengard P: Dopamine sensitive adenylate cyclase in the caudate nucleus of rat brain and its similarity to the "dopamine receptor . Proc Natl Acad Sci USA 69:2145-2149, 1972.Crossref 5. Clement-Cormier YC, Kebabian JW, Petzold GL, et al: Dopamine-sensitive adenylate cyclase in mammalian brain: A possible site of action of antipsychotic drugs . Proc Natl Acad Sci USA 71:1113-1117, 1974.Crossref 6. Miller RJ, Horn AJ, Iversen LL: The action of neuroleptic drugs on dopamine-stimulated adenosine cyclic 3',5' monophosphate production in rat neostriatum and limbic forebrain . Mol Pharmacol 10:759-766, 1974. 7. Neff NH, Costa E: Effect of tricyclic antidepressants and chlorpromazine on brain catecholamine systhesis, in Garattini S, Duke MN (eds): Proceedings of the First International Symposium on Antidepressant Drugs, series 122. New York, Excerpta Medica, 1966, pp 28-34. 8. Zivkovic B, Guidotti A, Revuelta A, et al: Effect of thioridazine, clozapine, and other antipsychotics on the kinetic state of tyrosine hydroxylase and on the turnover rate of dopamine in striatum and accumbens . J Pharmacol Exp Ther , to be published. 9. Zivkovic B, Guidotti A, Costa E: Effect of neuroleptics on striatal tyrosine hydroxylase: Change in the affinity for the pteridine cofactor . Mol Pharmacol 10:727-735, 1974. 10. Guidotti A, Costa E: A role of nicotinic receptors in the regulation of the adenylate cyclase of adrenal medulla . J Pharmacol Exp Ther 189:665-675, 1974. 11. Lowry OH, Rosebrough NJ, Farr AL, et al: Protein measurement with the folin phenol reagent . J Biol Chem 193:265-275, 1951.

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Aug 1, 1975

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