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Dominantly Inherited Keratitis

Dominantly Inherited Keratitis Abstract • A new, autosomal dominant keratitis is presented. The onset occurs in early childhood with episodes of red, irritated eyes but not recurrent erosions. There are no associated systemic abnormalities. The primary histopathologic features are vascularization and inflammation of the anterior corneal stroma, and replacement of Bowman's layer by fibrovascular tissue. Thus, this disease demonstrates characteristics of both a dystrophy with familial occurrence and early onset, and a degeneration with primary inflammation and vascularization. References 1. Apple DJ, Rabb MF: Clinicopathologic Correlation of Ocular Disease , ed 2. St Louis, CV Mosby Co, 1978, pp 77-106. 2. Grayson M: Diseases of the Cornea , ed 2. St Louis, CV Mosby Co, 1983, p 237. 3. Bron AJ, Tripathi RC: Corneal disorders , in Goldberg MF (ed): Genetic and Metabolic Eye Disease . Boston, Little Brown & Co Inc, 1974, p 281. 4. Witkop CJ, Shankle CH, Graham JB, et al: Hereditary benign intraepithelial dyskeratosis . Arch Pathol Lab Med 1960;70:696-711. 5. Yanoff M: Hereditary benign intraepithelial dyskeratosis . Arch Ophthalmol 1968;79:291-293.Crossref 6. Sallmann L, Paton D: Hereditary benign intraepithelial dyskeratosis . Arch Ophthalmol 1960;63:421-429.Crossref 7. Wilson FM, Grayson M, Pieroni D: Corneal changes in ectodermal dysplasia . Am J Ophthalmol 1973;75:17-27. 8. Mawhorter LG, Ruttum MS, Koenig SB: Keratopathy in a family with the ectrodactyly-ectodermal dysplasia-clefting syndrome . Ophthalmology 1985;92:1427-1431.Crossref 9. Hvidberg-Hanse J, Larsen FE, Kleener J: Dyskeratotic marginal keratoconjunctivitis in hereditary periodontopathy and hyperkeratosis . Acta Ophthalmol 1973;123( (suppl) ):157-161. 10. Cram DL, Renseck JS, Jackson WF: A congenital ichthyosiform syndrome with deafness and keratitis . Arch Dermatol 1979;115:467-471.Crossref 11. Skinner BA, Greist MC, Norins AL: The keratitis-ichthyosis-deafness (KID) syndrome . Arch Dermatol 1981;117-284-289.Crossref 12. Hirst LW, Farmer ER, Green WR, et al: Familial corneal scarring: A new dystrophy? Ophthalmology 1984;91:174-178.Crossref 13. Bateman JB, Pettit TH, Isenberg SJ, et al: Ligneous conjunctivitis: An autosomal recessive disorder . J Pediatr Ophthalmol Strabismus 1986;23:137-140. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1986.01050230059031
Publisher site
See Article on Publisher Site

Abstract

Abstract • A new, autosomal dominant keratitis is presented. The onset occurs in early childhood with episodes of red, irritated eyes but not recurrent erosions. There are no associated systemic abnormalities. The primary histopathologic features are vascularization and inflammation of the anterior corneal stroma, and replacement of Bowman's layer by fibrovascular tissue. Thus, this disease demonstrates characteristics of both a dystrophy with familial occurrence and early onset, and a degeneration with primary inflammation and vascularization. References 1. Apple DJ, Rabb MF: Clinicopathologic Correlation of Ocular Disease , ed 2. St Louis, CV Mosby Co, 1978, pp 77-106. 2. Grayson M: Diseases of the Cornea , ed 2. St Louis, CV Mosby Co, 1983, p 237. 3. Bron AJ, Tripathi RC: Corneal disorders , in Goldberg MF (ed): Genetic and Metabolic Eye Disease . Boston, Little Brown & Co Inc, 1974, p 281. 4. Witkop CJ, Shankle CH, Graham JB, et al: Hereditary benign intraepithelial dyskeratosis . Arch Pathol Lab Med 1960;70:696-711. 5. Yanoff M: Hereditary benign intraepithelial dyskeratosis . Arch Ophthalmol 1968;79:291-293.Crossref 6. Sallmann L, Paton D: Hereditary benign intraepithelial dyskeratosis . Arch Ophthalmol 1960;63:421-429.Crossref 7. Wilson FM, Grayson M, Pieroni D: Corneal changes in ectodermal dysplasia . Am J Ophthalmol 1973;75:17-27. 8. Mawhorter LG, Ruttum MS, Koenig SB: Keratopathy in a family with the ectrodactyly-ectodermal dysplasia-clefting syndrome . Ophthalmology 1985;92:1427-1431.Crossref 9. Hvidberg-Hanse J, Larsen FE, Kleener J: Dyskeratotic marginal keratoconjunctivitis in hereditary periodontopathy and hyperkeratosis . Acta Ophthalmol 1973;123( (suppl) ):157-161. 10. Cram DL, Renseck JS, Jackson WF: A congenital ichthyosiform syndrome with deafness and keratitis . Arch Dermatol 1979;115:467-471.Crossref 11. Skinner BA, Greist MC, Norins AL: The keratitis-ichthyosis-deafness (KID) syndrome . Arch Dermatol 1981;117-284-289.Crossref 12. Hirst LW, Farmer ER, Green WR, et al: Familial corneal scarring: A new dystrophy? Ophthalmology 1984;91:174-178.Crossref 13. Bateman JB, Pettit TH, Isenberg SJ, et al: Ligneous conjunctivitis: An autosomal recessive disorder . J Pediatr Ophthalmol Strabismus 1986;23:137-140.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1986

References