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Do Treponemes Survive Adequate Treatment of Late Syphilis?

Do Treponemes Survive Adequate Treatment of Late Syphilis? Abstract Nodes from 45 men who had been treated for syphilis in varying stages of the disease were studied. Five of these nodes were shown to contain treponeme-like forms, which in two cases proved to be virulent. Repeat node study after supervised treatment was completely negative in all five men. Possible reinfection and inadequacy of previous treatment undoubtedly are important factors in the original findings. Penicillin is the drug of choice in the treatment of syphilis. There is no evidence that Treponema pallidum survives in humans after adequate penicillin treatment. References 1. Collart, P.; Borel, L.; and Durel, P.: Experimental Late Syphilis , Ann Inst Pasteur (Paris) 102:597, 1962. 2. Collart, P.; Borel, L.; and Durel, P.: Late Human Syphilis: Persistence of Treponema pallidum After Treatment , Ann Inst Pasteur (Paris) 102:693, 1962. 3. Collart, P.: Persistence of Treponema pallidum in Late Syphilis in Rabbits and Humans, Notwithstanding Treatment , Proceedings World Forum on Syphilis and Other Treponematoses , Washington, DC, (Sept 4) -8, 1962, Public Health Service Publication No. 997. 4. Yobs, A. L.; Rockwell, D. H.; and Clark, J. W., Jr.: Treponemal Survival in Humans After Penicillin Therapy: Preliminary Report, December, 1964. 5. Edwards, E. A.: Detecting Treponema pallidum in Primary Lesions by Fluorescent Antibody Technique , Public Health Reports 77:427, 1962. 6. Yobs, A. R.; Brown, L.; and Hunter, E. F.: Fluorescent Antibody Technique in Early Syphilis , AMA Arch Path 77:220-225 ( (Feb) ) 1964. 7. Krajian, A. A.: Clinical Application of Twenty-Minute Staining Method for Spirochaeta pallida , Amer J Syph Gon Ven Dis 23:617-620, 1939. 8. Dieterle, R. R.: Method for Demonstration of Spirochaeta pallida in Single Microscopic Sections , Arch Neurol Psychiat 18:73-80, 1927.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Do Treponemes Survive Adequate Treatment of Late Syphilis?

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Publisher
American Medical Association
Copyright
Copyright © 1965 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1965.01600100095026
Publisher site
See Article on Publisher Site

Abstract

Abstract Nodes from 45 men who had been treated for syphilis in varying stages of the disease were studied. Five of these nodes were shown to contain treponeme-like forms, which in two cases proved to be virulent. Repeat node study after supervised treatment was completely negative in all five men. Possible reinfection and inadequacy of previous treatment undoubtedly are important factors in the original findings. Penicillin is the drug of choice in the treatment of syphilis. There is no evidence that Treponema pallidum survives in humans after adequate penicillin treatment. References 1. Collart, P.; Borel, L.; and Durel, P.: Experimental Late Syphilis , Ann Inst Pasteur (Paris) 102:597, 1962. 2. Collart, P.; Borel, L.; and Durel, P.: Late Human Syphilis: Persistence of Treponema pallidum After Treatment , Ann Inst Pasteur (Paris) 102:693, 1962. 3. Collart, P.: Persistence of Treponema pallidum in Late Syphilis in Rabbits and Humans, Notwithstanding Treatment , Proceedings World Forum on Syphilis and Other Treponematoses , Washington, DC, (Sept 4) -8, 1962, Public Health Service Publication No. 997. 4. Yobs, A. L.; Rockwell, D. H.; and Clark, J. W., Jr.: Treponemal Survival in Humans After Penicillin Therapy: Preliminary Report, December, 1964. 5. Edwards, E. A.: Detecting Treponema pallidum in Primary Lesions by Fluorescent Antibody Technique , Public Health Reports 77:427, 1962. 6. Yobs, A. R.; Brown, L.; and Hunter, E. F.: Fluorescent Antibody Technique in Early Syphilis , AMA Arch Path 77:220-225 ( (Feb) ) 1964. 7. Krajian, A. A.: Clinical Application of Twenty-Minute Staining Method for Spirochaeta pallida , Amer J Syph Gon Ven Dis 23:617-620, 1939. 8. Dieterle, R. R.: Method for Demonstration of Spirochaeta pallida in Single Microscopic Sections , Arch Neurol Psychiat 18:73-80, 1927.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1965

References