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Distribution Within the Cochlea of Dihydrostreptomycin Injected Into the Circulation: An Autoradiographic and Electron Microscopic Study

Distribution Within the Cochlea of Dihydrostreptomycin Injected Into the Circulation: An... Abstract Using tritiated dihydrostreptomycin sulfate, the details of the fixation of streptomycin within the organ of Corti were studied. Two guinea pigs were used, and the incorporation times were one hour in the first and four hours in the second. Injection of the drug was into the carotid artery in order to approximate therapeutic conditions. Streptomycin spreads by way of the perilymph, across Reissner membrane and the basilar membrane, to gain the supporting Deiters cells, and then to show a certain election for the ribosomal fractions of the outer hair cells. More detailed studies are required to confirm this interpretation. References 1. Balogh K, Hiraide F, Ishii D: Distribution of radioactive dihydrostreptomycin in the cochlea . Ann Otol Rhinol Laryngol 79:641, 1970. 2. Von Ilberg C, Spoendlin H, Arnold W: Autoradiographical distribution of locally applied dihydrostreptomycin in the inner ear . Acta Otolaryngol (Stockh) 71:159, 1971.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Distribution Within the Cochlea of Dihydrostreptomycin Injected Into the Circulation: An Autoradiographic and Electron Microscopic Study

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Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1974.00780040487014
Publisher site
See Article on Publisher Site

Abstract

Abstract Using tritiated dihydrostreptomycin sulfate, the details of the fixation of streptomycin within the organ of Corti were studied. Two guinea pigs were used, and the incorporation times were one hour in the first and four hours in the second. Injection of the drug was into the carotid artery in order to approximate therapeutic conditions. Streptomycin spreads by way of the perilymph, across Reissner membrane and the basilar membrane, to gain the supporting Deiters cells, and then to show a certain election for the ribosomal fractions of the outer hair cells. More detailed studies are required to confirm this interpretation. References 1. Balogh K, Hiraide F, Ishii D: Distribution of radioactive dihydrostreptomycin in the cochlea . Ann Otol Rhinol Laryngol 79:641, 1970. 2. Von Ilberg C, Spoendlin H, Arnold W: Autoradiographical distribution of locally applied dihydrostreptomycin in the inner ear . Acta Otolaryngol (Stockh) 71:159, 1971.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Dec 1, 1974

References