ORIGINAL ARTICLE Distinct Effects of 9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing Paolo Fusar-Poli, MD; Jose´ A. Crippa, MD, PhD; Sagnik Bhattacharyya, MD; Stefan J. Borgwardt, MD, PhD; Paul Allen, PhD; Rocio Martin-Santos, MD, PhD; Marc Seal, MD, PhD; Simon A. Surguladze, MD, PhD; Colin O’Carrol, PhD; Zerrin Atakan, MD, PhD; Antonio W. Zuardi, MD, PhD; Philip K. McGuire, MD, PhD Context: Cannabis use can both increase and reduce anxi- Results:9-Tetrahydrocannabinol increased anxiety, as ety in humans. The neurophysiological substrates of these well as levels of intoxication, sedation, and psychotic effects are unknown. symptoms, whereas there was a trend for a reduction in anxiety following administration of CBD. The number Objective: To investigate the effects of 2 main psycho- of SCR fluctuations during the processing of intensely active constituents of Cannabis sativa (9-tetrahydrocan- fearful faces increased following administration of 9- nabinol [9-THC] and cannabidiol [CBD]) on regional THC but decreased following administration of CBD. Can- brain function during emotional processing. nabidiol attenuated the blood oxygenation level– dependent signal in the amygdala and the anterior and Design: Subjects were studied on 3 separate occasions posterior cingulate cortex while subjects were process- using an event-related functional magnetic resonance ing
JAMA Psychiatry – American Medical Association
Published: Jan 1, 2009
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