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Distensibility Curves and Expansion Patterns of Newborn Lungs: The Unique Pattern of Lungs of Infants With Hyaline Membranes

Distensibility Curves and Expansion Patterns of Newborn Lungs: The Unique Pattern of Lungs of... Abstract It has been shown by Gribetz that the excised lungs of infants dying with respiratory distress do not expand well,1 and Cook et al 2 have demonstrated the reduced compliance of lungs of such infants during life. Gruenwald has indicated that the lungs of such infants will expand at pressures of 70 cm of water, but sustained pressures at this level are considered to be unobtainable during life in the newborn and very likely disruptive if achieved by external means.3 The static pressures employed in this paper may have little relation to the relatively high pressures momentarily obtained during inspiration, or the short sharp rises in intratracheal pressure during resuscitatory procedures. Several years ago we demonstrated the nature of the expanded pattern of lungs of infants dying with hyaline membranes by injection, reconstruction, and corrosion techniques.4 In these, it was found that the membranes appeared to obstruct References 1. Gribetz, I.; Frank, N. R.; and Avery, M. E.: Static Volume-Pressure Relations of Excised Lungs of Infants With Hyaline Membrane Disease, Newborn, and Stillborn Infants , J Clin Invest 38:2168, 1959.Crossref 2. Cook, C. D.; Sutherland, J. M.; Segal, S.; Cherry, R. B.; Mead, J.; McIlray, M. B.; and Smith, C. A.: Studies on Respiratory Physiology in the Newborn Infant: III. Measurements in Mechanics of Respiration , J Clin Invest 36:440, 1940.Crossref 3. Gruenwald, P.: The Significance of Pulmonary Hyaline Membranes in Newborn Infants , JAMA 166:621, 1958.Crossref 4. Craig, J. M.; Fenton, K.; and Gitlin, D.: Obstructive Factors in Pulmonary Hyaline Membrane Syndrome in Asphyxia of the Newborn, Pediatrics 22:847, 1958. 5. Pattle, R. E.: Properties, Function and Origin of the Alveolar Lining Layer, Proc Roy Soc (Biol) 148:217, 1958.Crossref 6. Avery, M. E., and Mead, J.: Surface Properties in Relation to Atelectasis and Hyaline Membrane Disease , Amer J Dis Child 97:517, 1959. 7. Clements, J. A.: Effects of Intrinsic Surface Active Material on the Mechanical Properties of Lungs With Special Reference to the Stability of Alveolar Structure , Amer Rev Resp Dis 81:742, 1960. 8. Clements, J.; Brown, E. S.; and Johnson, R. D.: Pulmonary Surface Tension and Mucus Lining of the Lungs: Some Theoretical Considerations , J Appl Physiol 13:262, 1958. 9. Mead, J.: Mechanical Properties of Lungs , Physiol Rev 41:281, 1961. 10. Agostoni, E.; Toglietti, A.; Agostoni, F.; and Setnikov, I.: Mechanical Aspects of the First Breath , J Appl Physiol 13:344, 1958. 11. Gruenwald, P.: Surface Tension as a Factor in the Resistance of Neonatal Lungs to Aeration , Amer J Obstet Gynec 53:996, 1947. 12. Boss, J. H., and Craig, J. M.: Reparative Phenomena in Lungs of Neonates With Hyaline Membranes , Pediatrics 29:891, 1962. 13. Radford, E. P.: Mechanical Factors Determining Alveolar Configuration , Amer Rev Resp Dis 81:743, 1960. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Distensibility Curves and Expansion Patterns of Newborn Lungs: The Unique Pattern of Lungs of Infants With Hyaline Membranes

American Journal of Diseases of Children , Volume 106 (2) – Aug 1, 1963

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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1963.02080050176010
Publisher site
See Article on Publisher Site

Abstract

Abstract It has been shown by Gribetz that the excised lungs of infants dying with respiratory distress do not expand well,1 and Cook et al 2 have demonstrated the reduced compliance of lungs of such infants during life. Gruenwald has indicated that the lungs of such infants will expand at pressures of 70 cm of water, but sustained pressures at this level are considered to be unobtainable during life in the newborn and very likely disruptive if achieved by external means.3 The static pressures employed in this paper may have little relation to the relatively high pressures momentarily obtained during inspiration, or the short sharp rises in intratracheal pressure during resuscitatory procedures. Several years ago we demonstrated the nature of the expanded pattern of lungs of infants dying with hyaline membranes by injection, reconstruction, and corrosion techniques.4 In these, it was found that the membranes appeared to obstruct References 1. Gribetz, I.; Frank, N. R.; and Avery, M. E.: Static Volume-Pressure Relations of Excised Lungs of Infants With Hyaline Membrane Disease, Newborn, and Stillborn Infants , J Clin Invest 38:2168, 1959.Crossref 2. Cook, C. D.; Sutherland, J. M.; Segal, S.; Cherry, R. B.; Mead, J.; McIlray, M. B.; and Smith, C. A.: Studies on Respiratory Physiology in the Newborn Infant: III. Measurements in Mechanics of Respiration , J Clin Invest 36:440, 1940.Crossref 3. Gruenwald, P.: The Significance of Pulmonary Hyaline Membranes in Newborn Infants , JAMA 166:621, 1958.Crossref 4. Craig, J. M.; Fenton, K.; and Gitlin, D.: Obstructive Factors in Pulmonary Hyaline Membrane Syndrome in Asphyxia of the Newborn, Pediatrics 22:847, 1958. 5. Pattle, R. E.: Properties, Function and Origin of the Alveolar Lining Layer, Proc Roy Soc (Biol) 148:217, 1958.Crossref 6. Avery, M. E., and Mead, J.: Surface Properties in Relation to Atelectasis and Hyaline Membrane Disease , Amer J Dis Child 97:517, 1959. 7. Clements, J. A.: Effects of Intrinsic Surface Active Material on the Mechanical Properties of Lungs With Special Reference to the Stability of Alveolar Structure , Amer Rev Resp Dis 81:742, 1960. 8. Clements, J.; Brown, E. S.; and Johnson, R. D.: Pulmonary Surface Tension and Mucus Lining of the Lungs: Some Theoretical Considerations , J Appl Physiol 13:262, 1958. 9. Mead, J.: Mechanical Properties of Lungs , Physiol Rev 41:281, 1961. 10. Agostoni, E.; Toglietti, A.; Agostoni, F.; and Setnikov, I.: Mechanical Aspects of the First Breath , J Appl Physiol 13:344, 1958. 11. Gruenwald, P.: Surface Tension as a Factor in the Resistance of Neonatal Lungs to Aeration , Amer J Obstet Gynec 53:996, 1947. 12. Boss, J. H., and Craig, J. M.: Reparative Phenomena in Lungs of Neonates With Hyaline Membranes , Pediatrics 29:891, 1962. 13. Radford, E. P.: Mechanical Factors Determining Alveolar Configuration , Amer Rev Resp Dis 81:743, 1960.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1963

References