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DISSEMINATION OF SPIROCHAETA PALLIDA IN EXPERIMENTAL SYPHILIS

DISSEMINATION OF SPIROCHAETA PALLIDA IN EXPERIMENTAL SYPHILIS Abstract The earliest studies of Schaudinn and Hoffmann1 pointed to a rapid invasion of the lymphatic glands by Spirochaeta pallida. Metchnikoff and Roux2 and Finger and Landsteiner3 were able to inoculate animals with lymph glands taken early in the course of infection. It was not until later that evidence was shown that in the absence of a primary lesion, spirochetes could be found in the circulation. For this discovery we are indebted to Reasoner,4 who, in 1916, demonstrated a generalized infection in rabbits from which the inoculated testicles had been removed before an initial lesion had fully developed. The obvious deduction from this study is that the dissemination of spirochetes occurs very early in the disease and that the primary focus of infection is not a measure of any subsequent reaction in the animal. Indeed, Reasoner found by experiment that the blood serum of an intratesticularly inoculated References 1. Schaudinn and Hoffmann: Arb. a. d. k. Gsndhtsamte 22:527, 1905. 2. Metchnikoff and Roux: System of Syphilis , ed. by D'Arcy Power and J. K. Murphy, 1914, Vol. 1. 3. Finger and Landsteiner: Arch. f. Dermat. u. Syph. 81-82:147, 152, 1906.Crossref 4. Reasoner, M. A.: Some Phases of Experimental Syphilis with Special Reference to the Question of Strains , J. A. M. A. 67:1799 ( (Dec. 16) ) 1916.Crossref 5. Wile, U. J.: Am. J. Syph. 1:84 ( (Jan.) ) 1917. 6. Zabolotny: Centralbl. f. Bakteriol. Ref. 38:13, 1905. 7. Uhlenhuth and Mulzer: Berl. klin. Wchnschr. 49:153, 1912 8. Uhlenhuth Berl. klin. Wchnschr. 50: 2031, 1913 9. Centralbl. f. Bakteriol., Orig. 64:165, 1912. 10. Brown, W. H., and Pearce, Louise: A Note on the Dissemination of Spirochaeta Pallida from the Primary Focus of Infection , Arch. Dermat. & Syph. 2:470 ( (Oct.) ) 1920. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

DISSEMINATION OF SPIROCHAETA PALLIDA IN EXPERIMENTAL SYPHILIS

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Publisher
American Medical Association
Copyright
Copyright © 1921 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1921.02350140003001
Publisher site
See Article on Publisher Site

Abstract

Abstract The earliest studies of Schaudinn and Hoffmann1 pointed to a rapid invasion of the lymphatic glands by Spirochaeta pallida. Metchnikoff and Roux2 and Finger and Landsteiner3 were able to inoculate animals with lymph glands taken early in the course of infection. It was not until later that evidence was shown that in the absence of a primary lesion, spirochetes could be found in the circulation. For this discovery we are indebted to Reasoner,4 who, in 1916, demonstrated a generalized infection in rabbits from which the inoculated testicles had been removed before an initial lesion had fully developed. The obvious deduction from this study is that the dissemination of spirochetes occurs very early in the disease and that the primary focus of infection is not a measure of any subsequent reaction in the animal. Indeed, Reasoner found by experiment that the blood serum of an intratesticularly inoculated References 1. Schaudinn and Hoffmann: Arb. a. d. k. Gsndhtsamte 22:527, 1905. 2. Metchnikoff and Roux: System of Syphilis , ed. by D'Arcy Power and J. K. Murphy, 1914, Vol. 1. 3. Finger and Landsteiner: Arch. f. Dermat. u. Syph. 81-82:147, 152, 1906.Crossref 4. Reasoner, M. A.: Some Phases of Experimental Syphilis with Special Reference to the Question of Strains , J. A. M. A. 67:1799 ( (Dec. 16) ) 1916.Crossref 5. Wile, U. J.: Am. J. Syph. 1:84 ( (Jan.) ) 1917. 6. Zabolotny: Centralbl. f. Bakteriol. Ref. 38:13, 1905. 7. Uhlenhuth and Mulzer: Berl. klin. Wchnschr. 49:153, 1912 8. Uhlenhuth Berl. klin. Wchnschr. 50: 2031, 1913 9. Centralbl. f. Bakteriol., Orig. 64:165, 1912. 10. Brown, W. H., and Pearce, Louise: A Note on the Dissemination of Spirochaeta Pallida from the Primary Focus of Infection , Arch. Dermat. & Syph. 2:470 ( (Oct.) ) 1920.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Feb 1, 1921

References