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DISSEMINATED ACTINOMYCOSIS TREATED WITH TETRACYCLINE

DISSEMINATED ACTINOMYCOSIS TREATED WITH TETRACYCLINE Abstract CASES in which localized actinomycosis has responded to members of the tetracycline group of compounds have been reported, but no case such as this one has been reported as far as we know, in which the actinomycosis was disseminated and seemed to respond to tetracycline.* REPORT OF CASE The patient was a white man, 39 years old, a supervisor in an aircraft plant. He came to the Mayo Clinic on Jan. 11, 1954, with a chief complaint of painful nodules under the skin and generously distributed throughout his body. History. —About 1941, curettage had been done twice weekly for about four months in treatment of severe pyorrhea. From 1941 to 1948 the patient frequently had had sore throat. In the summer of 1950 he had undergone two dental extractions.In October, 1950, several symptoms had become noteworthy. Bodily aching had been general, but the regions chiefly affected had been the References 1. The tetracycline (Achromycin) for this study was supplied through the courtesy of Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y. 2. References 4-9. 3. Nichols, D. R., and Herrell, W. E.: Penicillin in the Treatment of Actinomycosis , J. Lab. & Clin. Med. 33:521-525 ( (May) ) 1948. 4. Keefer, C. S.; Blake, F. G.; Marshall, E. K., Jr.; Lockwood, J. S., and Wood, W. B., Jr.: Penicillin in the Treatment of Infections: A Report of 500 Cases , J. A. M. A. 122:1217-1224 ( (Aug. 28) ) 1943. 5. Herrell, W. E.; Nichols, D. R., and Heilman, D. H.: Penicillin: Its Usefulness, Limitations, Diffusion and Detection, with Analysis of 150 Cases in Which It Was Employed , J. A. M. A. 125: 1003-1010 ( (Aug. 12) ) 1944. 6. Hamilton, A. J. C., and Kirkpatrick, H. J. R.: Actinomycosis Successfully Treated with Penicillin: Report of 2 Cases , Brit. M. J. 2:728 ( (Nov. 24) ) 1945. 7. Decker, H. R.: The Treatment of Thoracic Actinomycosis by Penicillin and Sulfonamide Drugs , J. Thoracic Surg. 15:430-440 ( (Dec.) ) 1946. 8. Poppe, J. K.: Treatment of Pulmonary Actinomycosis with a Report of 7 Arrested Cases , J. Thoracic Surg. 15:118-126 ( (April) ) 1946. 9. Lamb, J. H.; Lain, E. S., and Jones, P. E.: Actinomycosis of the Face and Neck , J. A. M. A. 134:351-359 ( (May 24) ) 1947. 10. Chanton, E. F.; Hollis, W. J., and Hargrove, M. D.: Actinomycosis: Report of 6 Cases Treated with Penicillin and Sulfadiazine , South, M. J. 41: 1022-1026 ( (Nov.) ) 1948. 11. Sanford, G. E., and Barnes, R. O.: Massive Penicillin Therapy of Abdominal Actinomycosis , Surgery 25:711-723 ( (May) ) 1949. 12. McVay, L. V., Jr., and Sprunt, D. H.: A Long-Term Evaluation of Aureomycin in the Treatment of Actinomycosis , Ann. Int. Med. 38:955-966 ( (May) ) 1953. 13. Seligman, S. A.: Treatment of Actinomycosis with Aureomycin , Brit. M. J. 1:1421 ( (June 19) ) 1954. 14. Lane, S. L., and Kutscher, A. H.: Oxytetra- cycline in the Treatment of Orocervical Facial Actinomycosis: Report of 7 Cases , J. A. M. A. 151:986-988 ( (March 21) ) 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1956.00250200128011
Publisher site
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Abstract

Abstract CASES in which localized actinomycosis has responded to members of the tetracycline group of compounds have been reported, but no case such as this one has been reported as far as we know, in which the actinomycosis was disseminated and seemed to respond to tetracycline.* REPORT OF CASE The patient was a white man, 39 years old, a supervisor in an aircraft plant. He came to the Mayo Clinic on Jan. 11, 1954, with a chief complaint of painful nodules under the skin and generously distributed throughout his body. History. —About 1941, curettage had been done twice weekly for about four months in treatment of severe pyorrhea. From 1941 to 1948 the patient frequently had had sore throat. In the summer of 1950 he had undergone two dental extractions.In October, 1950, several symptoms had become noteworthy. Bodily aching had been general, but the regions chiefly affected had been the References 1. The tetracycline (Achromycin) for this study was supplied through the courtesy of Lederle Laboratories Division, American Cyanamid Company, Pearl River, N. Y. 2. References 4-9. 3. Nichols, D. R., and Herrell, W. E.: Penicillin in the Treatment of Actinomycosis , J. Lab. & Clin. Med. 33:521-525 ( (May) ) 1948. 4. Keefer, C. S.; Blake, F. G.; Marshall, E. K., Jr.; Lockwood, J. S., and Wood, W. B., Jr.: Penicillin in the Treatment of Infections: A Report of 500 Cases , J. A. M. A. 122:1217-1224 ( (Aug. 28) ) 1943. 5. Herrell, W. E.; Nichols, D. R., and Heilman, D. H.: Penicillin: Its Usefulness, Limitations, Diffusion and Detection, with Analysis of 150 Cases in Which It Was Employed , J. A. M. A. 125: 1003-1010 ( (Aug. 12) ) 1944. 6. Hamilton, A. J. C., and Kirkpatrick, H. J. R.: Actinomycosis Successfully Treated with Penicillin: Report of 2 Cases , Brit. M. J. 2:728 ( (Nov. 24) ) 1945. 7. Decker, H. R.: The Treatment of Thoracic Actinomycosis by Penicillin and Sulfonamide Drugs , J. Thoracic Surg. 15:430-440 ( (Dec.) ) 1946. 8. Poppe, J. K.: Treatment of Pulmonary Actinomycosis with a Report of 7 Arrested Cases , J. Thoracic Surg. 15:118-126 ( (April) ) 1946. 9. Lamb, J. H.; Lain, E. S., and Jones, P. E.: Actinomycosis of the Face and Neck , J. A. M. A. 134:351-359 ( (May 24) ) 1947. 10. Chanton, E. F.; Hollis, W. J., and Hargrove, M. D.: Actinomycosis: Report of 6 Cases Treated with Penicillin and Sulfadiazine , South, M. J. 41: 1022-1026 ( (Nov.) ) 1948. 11. Sanford, G. E., and Barnes, R. O.: Massive Penicillin Therapy of Abdominal Actinomycosis , Surgery 25:711-723 ( (May) ) 1949. 12. McVay, L. V., Jr., and Sprunt, D. H.: A Long-Term Evaluation of Aureomycin in the Treatment of Actinomycosis , Ann. Int. Med. 38:955-966 ( (May) ) 1953. 13. Seligman, S. A.: Treatment of Actinomycosis with Aureomycin , Brit. M. J. 1:1421 ( (June 19) ) 1954. 14. Lane, S. L., and Kutscher, A. H.: Oxytetra- cycline in the Treatment of Orocervical Facial Actinomycosis: Report of 7 Cases , J. A. M. A. 151:986-988 ( (March 21) ) 1953.

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1956

References