Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Disordered Corticolimbic Interactions During Affective Processing in Children and Adolescents at Risk for Schizophrenia Revealed by Functional Magnetic Resonance Imaging and Dynamic Causal Modeling

Disordered Corticolimbic Interactions During Affective Processing in Children and Adolescents at... ORIGINAL ARTICLE Disordered Corticolimbic Interactions During Affective Processing in Children and Adolescents at Risk for Schizophrenia Revealed by Functional Magnetic Resonance Imaging and Dynamic Causal Modeling Vaibhav A. Diwadkar, PhD; Sunali Wadehra, MA; Patrick Pruitt, BS; Matcheri S. Keshavan, MD; Usha Rajan, MA; Caroline Zajac-Benitez, BA; Simon B. Eickhoff, DrMed Context: Disordered functional architecture of brain net- and adolescent offspring of a parent with schizophrenia works may contribute to the well-documented in- (age range, 8 to 20 years). creased risk for psychiatric disorders in offspring of pa- tients with schizophrenia. Results: Bayesian model selection revealed a winning model, the architecture of which revealed bidirectional Objective: To investigate aberrant interactions be- frontolimbic connections that were modulated by va- tween regions associated with affective processing in chil- lence. Analyses of parameter estimates revealed that HR- dren and adolescent offspring of patients with schizo- SCZ group members were characterized by (1) de- phrenia (HR-SCZ group) and healthy control subjects creased driving inputs to the visual cortex; (2) decreased using dynamic causal modeling of functional magnetic intrinsic coupling, most robustly between frontolimbic resonance imaging data. regions; and (3) increased modulatory inhibition by nega- tive valence of frontolimbic connections (all P .01, Bon- Design: http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Disordered Corticolimbic Interactions During Affective Processing in Children and Adolescents at Risk for Schizophrenia Revealed by Functional Magnetic Resonance Imaging and Dynamic Causal Modeling

Loading next page...
 
/lp/american-medical-association/disordered-corticolimbic-interactions-during-affective-processing-in-u99s5daAln
Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archgenpsychiatry.2011.1349
pmid
22393216
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Disordered Corticolimbic Interactions During Affective Processing in Children and Adolescents at Risk for Schizophrenia Revealed by Functional Magnetic Resonance Imaging and Dynamic Causal Modeling Vaibhav A. Diwadkar, PhD; Sunali Wadehra, MA; Patrick Pruitt, BS; Matcheri S. Keshavan, MD; Usha Rajan, MA; Caroline Zajac-Benitez, BA; Simon B. Eickhoff, DrMed Context: Disordered functional architecture of brain net- and adolescent offspring of a parent with schizophrenia works may contribute to the well-documented in- (age range, 8 to 20 years). creased risk for psychiatric disorders in offspring of pa- tients with schizophrenia. Results: Bayesian model selection revealed a winning model, the architecture of which revealed bidirectional Objective: To investigate aberrant interactions be- frontolimbic connections that were modulated by va- tween regions associated with affective processing in chil- lence. Analyses of parameter estimates revealed that HR- dren and adolescent offspring of patients with schizo- SCZ group members were characterized by (1) de- phrenia (HR-SCZ group) and healthy control subjects creased driving inputs to the visual cortex; (2) decreased using dynamic causal modeling of functional magnetic intrinsic coupling, most robustly between frontolimbic resonance imaging data. regions; and (3) increased modulatory inhibition by nega- tive valence of frontolimbic connections (all P .01, Bon- Design:

Journal

JAMA PsychiatryAmerican Medical Association

Published: Mar 1, 2012

References