ORIGINAL ARTICLE Disordered Corticolimbic Interactions During Affective Processing in Children and Adolescents at Risk for Schizophrenia Revealed by Functional Magnetic Resonance Imaging and Dynamic Causal Modeling Vaibhav A. Diwadkar, PhD; Sunali Wadehra, MA; Patrick Pruitt, BS; Matcheri S. Keshavan, MD; Usha Rajan, MA; Caroline Zajac-Benitez, BA; Simon B. Eickhoff, DrMed Context: Disordered functional architecture of brain net- and adolescent offspring of a parent with schizophrenia works may contribute to the well-documented in- (age range, 8 to 20 years). creased risk for psychiatric disorders in offspring of pa- tients with schizophrenia. Results: Bayesian model selection revealed a winning model, the architecture of which revealed bidirectional Objective: To investigate aberrant interactions be- frontolimbic connections that were modulated by va- tween regions associated with affective processing in chil- lence. Analyses of parameter estimates revealed that HR- dren and adolescent offspring of patients with schizo- SCZ group members were characterized by (1) de- phrenia (HR-SCZ group) and healthy control subjects creased driving inputs to the visual cortex; (2) decreased using dynamic causal modeling of functional magnetic intrinsic coupling, most robustly between frontolimbic resonance imaging data. regions; and (3) increased modulatory inhibition by nega- tive valence of frontolimbic connections (all P .01, Bon- Design:
JAMA Psychiatry – American Medical Association
Published: Mar 1, 2012
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