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Discrete Papular Mucinosis Responding to Intralesional and Topical Steroids

Discrete Papular Mucinosis Responding to Intralesional and Topical Steroids Abstract To the Editor.— The treatment of papular mucinosis is usually unsatisfactory, but we describe here a patient with discrete papular mucinosis whose lesions responded to therapy with intralesional and topical steroids. Report of a Case.— A 32-year-old man presented with multiple discrete nodules over his limbs and chest. The patient reported that he had these nodules for 4 years. The lesions had appeared within a few months and then remained unchanged.Findings from his physical examination revealed numerous skincolored papules, mainly over the upper limbs (Fig 1), with one or two lesions over the back and legs.A skin biopsy specimen of one papule from the arm showed a loose, irregular proliferation of spindle cells in the dermis, in places following a storiform pattern (Fig 2). Irregular bundles of collagen and a moderate perivascular infiltrate, consisting mostly of plasma cells, were seen. Sections of the papular lesion were stained with References 1. Montgomery H, Underwood LJ. Lichen myxedematosus (differentiation from cutaneous myxedema or mucoid states) . J Invest Dermatol. 1953;20:213-236. 2. Rongioletti F, Rebora A, Crovato F. Acral persistent papular mucinosis: a new entity? Arch Dermatol. 1986;122:1237-1239.Crossref 3. Rongioletti F, Rebora A. The new cutaneous mucinoses: a review with an up-to-date classification of cutaneous mucinoses . J Am Acad Dermatol. 1991; 24:265-270.Crossref 4. Cosky RJ, Mehregan A. Papular mucinosis . Int J Dermatol. 1977;16:741-744.Crossref 5. Truhan AP, Roenigk HH Jr. The cutaneous mucinoses . J Am Acad Dermatol. 1986;14:1-18.Crossref 6. Feldman P, Shapiro L, Pick AI, et al. Scleromyxedema: a dramatic response to melphalan . Arch Dermatol. 1969;99:51-56.Crossref 7. Harris RB, Perry HO, Kyle RA, et al. Treatment of scleromyxedema with melphalan . Arch Dermatol. 1979;115:295-299.Crossref 8. Howsden SM, Herndon JH, Freeman RG. Lichen myxedematosus: a dermal infiltrative disorder responsive to cyclophosphamide therapy . Arch Dermatol. 1975;111:1325-1330.Crossref 9. Jessen RT, Strait M, Becker LE. Lichen myxedematosus: treatment with cyclophosphamide . Int J Dermatol. 1978;17:733-839. 10. Naeyaert JM. Papular mucinosis . Dermatologica . 1985;171:508. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Discrete Papular Mucinosis Responding to Intralesional and Topical Steroids

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Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1992.01680160147031
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— The treatment of papular mucinosis is usually unsatisfactory, but we describe here a patient with discrete papular mucinosis whose lesions responded to therapy with intralesional and topical steroids. Report of a Case.— A 32-year-old man presented with multiple discrete nodules over his limbs and chest. The patient reported that he had these nodules for 4 years. The lesions had appeared within a few months and then remained unchanged.Findings from his physical examination revealed numerous skincolored papules, mainly over the upper limbs (Fig 1), with one or two lesions over the back and legs.A skin biopsy specimen of one papule from the arm showed a loose, irregular proliferation of spindle cells in the dermis, in places following a storiform pattern (Fig 2). Irregular bundles of collagen and a moderate perivascular infiltrate, consisting mostly of plasma cells, were seen. Sections of the papular lesion were stained with References 1. Montgomery H, Underwood LJ. Lichen myxedematosus (differentiation from cutaneous myxedema or mucoid states) . J Invest Dermatol. 1953;20:213-236. 2. Rongioletti F, Rebora A, Crovato F. Acral persistent papular mucinosis: a new entity? Arch Dermatol. 1986;122:1237-1239.Crossref 3. Rongioletti F, Rebora A. The new cutaneous mucinoses: a review with an up-to-date classification of cutaneous mucinoses . J Am Acad Dermatol. 1991; 24:265-270.Crossref 4. Cosky RJ, Mehregan A. Papular mucinosis . Int J Dermatol. 1977;16:741-744.Crossref 5. Truhan AP, Roenigk HH Jr. The cutaneous mucinoses . J Am Acad Dermatol. 1986;14:1-18.Crossref 6. Feldman P, Shapiro L, Pick AI, et al. Scleromyxedema: a dramatic response to melphalan . Arch Dermatol. 1969;99:51-56.Crossref 7. Harris RB, Perry HO, Kyle RA, et al. Treatment of scleromyxedema with melphalan . Arch Dermatol. 1979;115:295-299.Crossref 8. Howsden SM, Herndon JH, Freeman RG. Lichen myxedematosus: a dermal infiltrative disorder responsive to cyclophosphamide therapy . Arch Dermatol. 1975;111:1325-1330.Crossref 9. Jessen RT, Strait M, Becker LE. Lichen myxedematosus: treatment with cyclophosphamide . Int J Dermatol. 1978;17:733-839. 10. Naeyaert JM. Papular mucinosis . Dermatologica . 1985;171:508.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1992

References

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