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DISCORDANCE OF CRETINISM IN MONOZYGOTIC TWINS

DISCORDANCE OF CRETINISM IN MONOZYGOTIC TWINS Abstract SPORADIC (nongoitrous) cretinism occurring in one of monozygotic twins strongly suggests the etiology of that condition to be not genetically conditioned but, rather, related to direct influences of environmental factors on the development of the thyroid anlage in the fetus. This is to be differentiated from goitrous sporadic cretinism, which is thought to be genetically conditioned.1 The near absence of familial coincidence of nongoitrous sporadic cretinism lends further support to that hypothesis. To date, three proved instances, and one probable, of discordant cretinism in monozygotic twins are reported.* In contrast, where congenital disorders are considered genetically conditioned, it is common to observe manifest disease in each of identical twins; for example, in known instances where vitamin-D-resistant rickets has occurred in one monozygotic twin, it has also been present in the others.† This communication records a fourth proved instance of discordance between identical twins, one of whom manifested congenital cretinism. References 1. Wilkins, L.; Clayton, G. W., and Berthrong, M.: Development of Goiters in Cretins Without Iodine Deficiency: Hypothyroidism Due to Apparent Inability of the Thyroid Gland to Synthesize Hormone , Pediatrics 13:235-246, 1954. 2. Grebe, H.: Diskordanzursachen bei erbgleichen Zwillingen , Acta genet. med. et gemel. 1:89-102, 1952. 3. von Harnack, G. A.: Eineiige Zwillinge mit diskordanter Hypothyreose , Arch. Kinderh. 146: 60-63, 1953. 4. Warkany, J., and Selkirk, T. K.: Discordant Monozygotic Twins: Hypothyroidism , A. M. A. Am. J. Dis. Child. 89:144-148, 1955. 5. Faxén, N.: Hypothyroidism in One of Twins , Acta paediat . 17:565-573, 1935.Crossref 6. McCune, D. J.: Refractory Rickets in Identical Twins , Am. J. Dis. Child. 63:1008, 1942. 7. Merrill, J. P.; Murray, J. E.; Harrison, J. H., and Guild, W. R.: Successful Homotransplantation of the Human Kidney Between Identical Twins , J. A. M. A. 160:277-282, 1956.Crossref 8. Pickering, D. E., and Lusted, L. B.: Thyroid Deficiency in Infants and Children , GP 11: 99-103, 1955. 9. Fisher, D. A.; Hammond, G. D., and Pickering, D. E.: The Hypothyroid Infant and Child: Therapy with Sodium 1-Thyroxine A. M. A. Am. J. Dis Child. 90:6-21, 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

DISCORDANCE OF CRETINISM IN MONOZYGOTIC TWINS

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1956.02060030057013
Publisher site
See Article on Publisher Site

Abstract

Abstract SPORADIC (nongoitrous) cretinism occurring in one of monozygotic twins strongly suggests the etiology of that condition to be not genetically conditioned but, rather, related to direct influences of environmental factors on the development of the thyroid anlage in the fetus. This is to be differentiated from goitrous sporadic cretinism, which is thought to be genetically conditioned.1 The near absence of familial coincidence of nongoitrous sporadic cretinism lends further support to that hypothesis. To date, three proved instances, and one probable, of discordant cretinism in monozygotic twins are reported.* In contrast, where congenital disorders are considered genetically conditioned, it is common to observe manifest disease in each of identical twins; for example, in known instances where vitamin-D-resistant rickets has occurred in one monozygotic twin, it has also been present in the others.† This communication records a fourth proved instance of discordance between identical twins, one of whom manifested congenital cretinism. References 1. Wilkins, L.; Clayton, G. W., and Berthrong, M.: Development of Goiters in Cretins Without Iodine Deficiency: Hypothyroidism Due to Apparent Inability of the Thyroid Gland to Synthesize Hormone , Pediatrics 13:235-246, 1954. 2. Grebe, H.: Diskordanzursachen bei erbgleichen Zwillingen , Acta genet. med. et gemel. 1:89-102, 1952. 3. von Harnack, G. A.: Eineiige Zwillinge mit diskordanter Hypothyreose , Arch. Kinderh. 146: 60-63, 1953. 4. Warkany, J., and Selkirk, T. K.: Discordant Monozygotic Twins: Hypothyroidism , A. M. A. Am. J. Dis. Child. 89:144-148, 1955. 5. Faxén, N.: Hypothyroidism in One of Twins , Acta paediat . 17:565-573, 1935.Crossref 6. McCune, D. J.: Refractory Rickets in Identical Twins , Am. J. Dis. Child. 63:1008, 1942. 7. Merrill, J. P.; Murray, J. E.; Harrison, J. H., and Guild, W. R.: Successful Homotransplantation of the Human Kidney Between Identical Twins , J. A. M. A. 160:277-282, 1956.Crossref 8. Pickering, D. E., and Lusted, L. B.: Thyroid Deficiency in Infants and Children , GP 11: 99-103, 1955. 9. Fisher, D. A.; Hammond, G. D., and Pickering, D. E.: The Hypothyroid Infant and Child: Therapy with Sodium 1-Thyroxine A. M. A. Am. J. Dis Child. 90:6-21, 1955.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Jul 1, 1956

References