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DIPHENHYDRAMINE (BENADRYL) AND TRIPELENNAMINE (PYRIBENZAMINE) INTOXICATION IN CHILDREN

DIPHENHYDRAMINE (BENADRYL) AND TRIPELENNAMINE (PYRIBENZAMINE) INTOXICATION IN CHILDREN IN VIEW of their widespread use in the therapy of allergic and associated disease, it seems wise to review the hazards of acute intoxication due to diphenhydramine (Benadryl) and tripelennamine (Pyribenzamine). The consumption of these agents has become enormous1; the associated hazards of indiscriminate use are the cause of great concern.2 Toxic doses frequently cause many troublesome side effects and severe reactions, which can be the cause of death. This is our great concern. This paper will review the pharmacology and toxic manifestations of diphenhydramine and tripelennamine and will present two cases showing the divergent effects of severe central nervous system intoxication in children. PHARMACOLOGY Tripelennamine and diphenhydramine, when given by mouth, are completely and rapidly absorbed, but traces of the drugs can be found in the gastrointestinal tract four hours after administration.3 The drugs rapidly leave the blood stream and localize in the various tissues. There http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

DIPHENHYDRAMINE (BENADRYL) AND TRIPELENNAMINE (PYRIBENZAMINE) INTOXICATION IN CHILDREN

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Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1953.02050070560003
Publisher site
See Article on Publisher Site

Abstract

IN VIEW of their widespread use in the therapy of allergic and associated disease, it seems wise to review the hazards of acute intoxication due to diphenhydramine (Benadryl) and tripelennamine (Pyribenzamine). The consumption of these agents has become enormous1; the associated hazards of indiscriminate use are the cause of great concern.2 Toxic doses frequently cause many troublesome side effects and severe reactions, which can be the cause of death. This is our great concern. This paper will review the pharmacology and toxic manifestations of diphenhydramine and tripelennamine and will present two cases showing the divergent effects of severe central nervous system intoxication in children. PHARMACOLOGY Tripelennamine and diphenhydramine, when given by mouth, are completely and rapidly absorbed, but traces of the drugs can be found in the gastrointestinal tract four hours after administration.3 The drugs rapidly leave the blood stream and localize in the various tissues. There

Journal

American journal of diseases of childrenAmerican Medical Association

Published: May 1, 1953

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