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Dihydrotachysterol and Vitamin D Resistance in Renal Failure

Dihydrotachysterol and Vitamin D Resistance in Renal Failure Abstract Vitamin D and dihydrotachysterol have been used for the treatment of hypoparathyroidism and osteomalacia for many years. Recently, experimental and clinical evidence has suggested that these compounds under certain circumstances may have quite different potencies when expressed on a weight basis.1,2 This report illustrates this phenomenon. Patient Summary A 56-year-old English-born nurse was first found to have hypertension at the age of 33 years. Investigation revealed a blood pressure of 180/110 mm Hg and normal results of urinalysis. The blood urea level was 26 mg/100 ml (normal, 20 to 40 mg/100 ml). Subsequent symptoms included constipation and one episode of colicky abdominal pain with dysuria. A lumbar sympathectomy was carried out for her hypertension when she was 36 years of age. At the age of 50 years the patient was found to be hypercalcemic and to have mild renal failure and was placed on reserpine therapy. Her laboratory findings References 1. Harrison HC, Harrison HE: Comparison of activity of 25-hydroxy cholecalciferol dihydrotachysterol in the thyroparathyroidectomised rat. Proc Soc Exp Biol Med 136:411-414, 1971.Crossref 2. Kaye M, Chatterjee G, Cohen GF, et al: Arrest of hyperparathyroid bone disease with dihydrotachysterol in patients undergoing chronic hemodialysis. Ann Intern Med 73:225-233, 1970.Crossref 3. Suda T, Hallick RB, DeLuca HF, et al: 25-Hydroxydihydrotachysterol: Synthesis of biological activity. Biochemistry 9:1651-1657, 1970.Crossref 4. Lawson DEM, Pelc B, Bell PA, et al: Synthesis of (1,2-3H2) cholecalciferol and metabolism of (4-14C,1,2-3H2)- and (4-14C,) 1-3H)-cholecalciferol in rachitic rat and chicks. Biochem J 121:673-682,1971. 5. Fraser DR, Kodicek E: Unique biosynthesis by kidney of a biologically active vitamin D metabolite. Nature 228:764-766, 1970.Crossref 6. Holick MF, Schnoes HK, DeLuca HF: Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine. Proc Nat Acad Sci USA 68:803-804, 1971.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Dihydrotachysterol and Vitamin D Resistance in Renal Failure

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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1972.03650050086017
Publisher site
See Article on Publisher Site

Abstract

Abstract Vitamin D and dihydrotachysterol have been used for the treatment of hypoparathyroidism and osteomalacia for many years. Recently, experimental and clinical evidence has suggested that these compounds under certain circumstances may have quite different potencies when expressed on a weight basis.1,2 This report illustrates this phenomenon. Patient Summary A 56-year-old English-born nurse was first found to have hypertension at the age of 33 years. Investigation revealed a blood pressure of 180/110 mm Hg and normal results of urinalysis. The blood urea level was 26 mg/100 ml (normal, 20 to 40 mg/100 ml). Subsequent symptoms included constipation and one episode of colicky abdominal pain with dysuria. A lumbar sympathectomy was carried out for her hypertension when she was 36 years of age. At the age of 50 years the patient was found to be hypercalcemic and to have mild renal failure and was placed on reserpine therapy. Her laboratory findings References 1. Harrison HC, Harrison HE: Comparison of activity of 25-hydroxy cholecalciferol dihydrotachysterol in the thyroparathyroidectomised rat. Proc Soc Exp Biol Med 136:411-414, 1971.Crossref 2. Kaye M, Chatterjee G, Cohen GF, et al: Arrest of hyperparathyroid bone disease with dihydrotachysterol in patients undergoing chronic hemodialysis. Ann Intern Med 73:225-233, 1970.Crossref 3. Suda T, Hallick RB, DeLuca HF, et al: 25-Hydroxydihydrotachysterol: Synthesis of biological activity. Biochemistry 9:1651-1657, 1970.Crossref 4. Lawson DEM, Pelc B, Bell PA, et al: Synthesis of (1,2-3H2) cholecalciferol and metabolism of (4-14C,1,2-3H2)- and (4-14C,) 1-3H)-cholecalciferol in rachitic rat and chicks. Biochem J 121:673-682,1971. 5. Fraser DR, Kodicek E: Unique biosynthesis by kidney of a biologically active vitamin D metabolite. Nature 228:764-766, 1970.Crossref 6. Holick MF, Schnoes HK, DeLuca HF: Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine. Proc Nat Acad Sci USA 68:803-804, 1971.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Nov 1, 1972

References