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Diffuse Keratoconjunctival Proliferation

Diffuse Keratoconjunctival Proliferation CLINICAL SCIENCES A Novel Clinical Manifestation Dalia G. Said, MD, FRCS; Manu Mathew, MSc, DipNB, MNAMS, FRCOphth, FRCS; M. Yusuf Shaikh, FRCS; V. Senthil Maharajan, MD, FRCS; James Lowe, FRCPath, PhD; Harminder S. Dua, MBBS, DO, DO(Lond), MS, MNAMS, FRCSEd, FRCOphth Objective: To report a previously unrecognized be- moderate number of active fibroblasts, numerous blood nign bilateral widespread conjunctival and corneal pro- vessels, and no elastotic degeneration in 3 of the 6 eyes. liferative condition with a potential to affect vision. Two eyes showed mild subepithelial elastotic degenera- tion, and 1 lesion was difficult to interpret because of ex- Methods: A gradually progressive diffuse conjunctival cessive intraconjunctival hemorrhage. None showed any proliferation extending on the cornea was noted in 14 inflammatory activity. patients (28 eyes). These patients were followed up for a mean of 6 years for the site, extent, and progression of Conclusions: The lesions appear to be a clinical variant the condition. Six eyes had these lesions removed and of classic pterygium with the corneal encroachment being studied histopathologically. wider, irregular, and more extensive. Histologically, a non- inflammatory nonelastotic collagenous accumulation ap- Results: Patients included 6 men and 8 women (mean pears to be a predominant feature http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

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References (20)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/archopht.126.9.1226
pmid
18779482
Publisher site
See Article on Publisher Site

Abstract

CLINICAL SCIENCES A Novel Clinical Manifestation Dalia G. Said, MD, FRCS; Manu Mathew, MSc, DipNB, MNAMS, FRCOphth, FRCS; M. Yusuf Shaikh, FRCS; V. Senthil Maharajan, MD, FRCS; James Lowe, FRCPath, PhD; Harminder S. Dua, MBBS, DO, DO(Lond), MS, MNAMS, FRCSEd, FRCOphth Objective: To report a previously unrecognized be- moderate number of active fibroblasts, numerous blood nign bilateral widespread conjunctival and corneal pro- vessels, and no elastotic degeneration in 3 of the 6 eyes. liferative condition with a potential to affect vision. Two eyes showed mild subepithelial elastotic degenera- tion, and 1 lesion was difficult to interpret because of ex- Methods: A gradually progressive diffuse conjunctival cessive intraconjunctival hemorrhage. None showed any proliferation extending on the cornea was noted in 14 inflammatory activity. patients (28 eyes). These patients were followed up for a mean of 6 years for the site, extent, and progression of Conclusions: The lesions appear to be a clinical variant the condition. Six eyes had these lesions removed and of classic pterygium with the corneal encroachment being studied histopathologically. wider, irregular, and more extensive. Histologically, a non- inflammatory nonelastotic collagenous accumulation ap- Results: Patients included 6 men and 8 women (mean pears to be a predominant feature

Journal

JAMA OphthalmologyAmerican Medical Association

Published: Sep 1, 2008

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