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Diffuse Hyperkeratosis in a Deaf and Blind 48-Year-Old Woman—Quiz Case

Diffuse Hyperkeratosis in a Deaf and Blind 48-Year-Old Woman—Quiz Case Report of a case A 48-year-old deaf and blind woman was transferred from an outside hospital for a severe flare of “psoriasis.” Findings from the clinical examination were impressive, revealing diffuse, thick scaling and serum crusting of the scalp with severe, patchy alopecia, and complete absence of the eyelashes and eyebrows. She had generalized mild erythroderma with massive cobblestone-like hyperkeratotic plaques of the trunk and extremities. Her palms demonstrated a diffuse grainy keratoderma, and her soles had extensive hyperkeratosis with deep fissures (Figure 1). Her corneas were opaque, and she had thick scaling on the face with perioral radial fissures (Figure 2). No mucosal lesions were seen. We further discovered that her skin disease and deafness were congenital, but her vision loss had been progressive into her 20s, when she underwent a corneal transplant that was unsuccessful. Two punch biopsies were performed and stained with hematoxylin-eosin and periodic acid–Schiff (PAS) (Figure 3). View LargeDownload Figure 1. View LargeDownload Figure 2. View LargeDownload Figure 3. What is your diagnosis? http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Diffuse Hyperkeratosis in a Deaf and Blind 48-Year-Old Woman—Quiz Case

Diffuse Hyperkeratosis in a Deaf and Blind 48-Year-Old Woman—Quiz Case

Abstract

Report of a case A 48-year-old deaf and blind woman was transferred from an outside hospital for a severe flare of “psoriasis.” Findings from the clinical examination were impressive, revealing diffuse, thick scaling and serum crusting of the scalp with severe, patchy alopecia, and complete absence of the eyelashes and eyebrows. She had generalized mild erythroderma with massive cobblestone-like hyperkeratotic plaques of the trunk and extremities. Her palms demonstrated a diffuse...
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Publisher
American Medical Association
Copyright
Copyright © 2012 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.148.10.1199-c
Publisher site
See Article on Publisher Site

Abstract

Report of a case A 48-year-old deaf and blind woman was transferred from an outside hospital for a severe flare of “psoriasis.” Findings from the clinical examination were impressive, revealing diffuse, thick scaling and serum crusting of the scalp with severe, patchy alopecia, and complete absence of the eyelashes and eyebrows. She had generalized mild erythroderma with massive cobblestone-like hyperkeratotic plaques of the trunk and extremities. Her palms demonstrated a diffuse grainy keratoderma, and her soles had extensive hyperkeratosis with deep fissures (Figure 1). Her corneas were opaque, and she had thick scaling on the face with perioral radial fissures (Figure 2). No mucosal lesions were seen. We further discovered that her skin disease and deafness were congenital, but her vision loss had been progressive into her 20s, when she underwent a corneal transplant that was unsuccessful. Two punch biopsies were performed and stained with hematoxylin-eosin and periodic acid–Schiff (PAS) (Figure 3). View LargeDownload Figure 1. View LargeDownload Figure 2. View LargeDownload Figure 3. What is your diagnosis?

Journal

Archives of DermatologyAmerican Medical Association

Published: Oct 1, 2012

Keywords: hearing impaired persons,keratosis

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