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DIFFERENTIAL SENSITIVITY OF SARCOMA AND NORMAL TISSUES TO TEMPORARY ARREST OF CIRCULATION

DIFFERENTIAL SENSITIVITY OF SARCOMA AND NORMAL TISSUES TO TEMPORARY ARREST OF CIRCULATION Abstract Warburg, Wind and Negelein1 suggested that tumor cells should be particularly sensitive to lack of nutrition because of their high metabolic rate. This conception seems to be borne out by the fact that Jensen's sarcoma undergoes extensive necrosis in rats which are exposed to 5 per cent oxygen for forty hours.1 Okamoto2 and Warburg. Wind and Negelein1 have shown that tumor cells remain viable after prolonged exposure to environments lacking either dextrose or oxygen. In a medium lacking both dextrose and oxygen, however, tumor cells die very rapidly; so it was found impossible to transplant the Jensen sarcoma after only four hours in such a medium. Furthermore, when a tumor-bearing animal was killed and kept at 37 C. for four hours after death, slices of tumor tissue placed in a medium containing dextrose and oxygen no longer metabolized, indicating irreversible destruction of the tumor cells.1 References 1. Warburg, O.; Wind, F., and Negelein, E.: Ueber den Stoffwechsel der Tumoren im Körper , Klin. Wchnschr. 5:529, 1926. 2. Okamoto, Y.: Ueber Anaerobiose von Tumorgewebe , Biochem. Ztschr. 160:52, 1926. 3. Allen, F. M.: Effects of Local Reaction in Spontaneous Tumors of Animals and Human Beings , Arch. Surg. 41:79 ( (July) ) 1940.Crossref 4. Allen, F. M.: Influence of Local Asphyxia, Organ Extracts and Temperature Changes on Engrafted Subcutaneous and Visceral Tumors in Rats , Urol. & Cutan. Rev. 44:12, 1940. 5. Allen, F. M.: Ligation Treatment of Chicken Sarcoma , M. Rec. 152:87, 1940. 6. Allen, F. M.: The Tourniquet and Local Asphyxia , Am. J. Surg. 41:192, 1938. 7. Allen, F. M.: Physical and Toxic Factors in Shock , Arch. Surg. 38:155 ( (Jan.) ) 1939. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

DIFFERENTIAL SENSITIVITY OF SARCOMA AND NORMAL TISSUES TO TEMPORARY ARREST OF CIRCULATION

Archives of Surgery , Volume 42 (5) – May 1, 1941

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Publisher
American Medical Association
Copyright
Copyright © 1941 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1941.01210110119010
Publisher site
See Article on Publisher Site

Abstract

Abstract Warburg, Wind and Negelein1 suggested that tumor cells should be particularly sensitive to lack of nutrition because of their high metabolic rate. This conception seems to be borne out by the fact that Jensen's sarcoma undergoes extensive necrosis in rats which are exposed to 5 per cent oxygen for forty hours.1 Okamoto2 and Warburg. Wind and Negelein1 have shown that tumor cells remain viable after prolonged exposure to environments lacking either dextrose or oxygen. In a medium lacking both dextrose and oxygen, however, tumor cells die very rapidly; so it was found impossible to transplant the Jensen sarcoma after only four hours in such a medium. Furthermore, when a tumor-bearing animal was killed and kept at 37 C. for four hours after death, slices of tumor tissue placed in a medium containing dextrose and oxygen no longer metabolized, indicating irreversible destruction of the tumor cells.1 References 1. Warburg, O.; Wind, F., and Negelein, E.: Ueber den Stoffwechsel der Tumoren im Körper , Klin. Wchnschr. 5:529, 1926. 2. Okamoto, Y.: Ueber Anaerobiose von Tumorgewebe , Biochem. Ztschr. 160:52, 1926. 3. Allen, F. M.: Effects of Local Reaction in Spontaneous Tumors of Animals and Human Beings , Arch. Surg. 41:79 ( (July) ) 1940.Crossref 4. Allen, F. M.: Influence of Local Asphyxia, Organ Extracts and Temperature Changes on Engrafted Subcutaneous and Visceral Tumors in Rats , Urol. & Cutan. Rev. 44:12, 1940. 5. Allen, F. M.: Ligation Treatment of Chicken Sarcoma , M. Rec. 152:87, 1940. 6. Allen, F. M.: The Tourniquet and Local Asphyxia , Am. J. Surg. 41:192, 1938. 7. Allen, F. M.: Physical and Toxic Factors in Shock , Arch. Surg. 38:155 ( (Jan.) ) 1939.

Journal

Archives of SurgeryAmerican Medical Association

Published: May 1, 1941

References