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Differential Effects of Aspirin Before and After Diagnosis of Colorectal Cancer

Differential Effects of Aspirin Before and After Diagnosis of Colorectal Cancer Editorials represent the opinions EDITORIAL of the authors and JAMA and not those of the American Medical Association. Differential Effects of Aspirin Before and After Diagnosis of Colorectal Cancer subtypes of colorectal cancer aspirin most effectively pre- Boris Pasche, MD, PhD vents both before and after diagnosis. In 2009, Chan et al demonstrated that regular aspirin intake after diagnosis of LTHOUGH MORBIDITY AND MORTALITY FROM COLO- colorectal cancer in patients whose primary tumors over- rectal cancer have steadily decreased over the past expressed PTGS2 as assessed by immunohistochemistry was 3 decades, colorectal cancer remains the third most associated with a 60% decreased risk of colorectal cancer– Acommon form of cancer and the third most com- specific mortality. In contrast, there was no association be- mon cause of cancer death in the United States. Early dis- tween aspirin use and lower mortality risk among patients ease detection through increases in screening that can iden- whose primary tumors had weak or absent PTGS2 expres- tify and allow removal of precancerous polyps is thought sion. In 2012, Liao et al tested the hypothesis that muta- to be the major reason for the decrease in colorectal cancer tions in the PIK3CA gene, one http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Differential Effects of Aspirin Before and After Diagnosis of Colorectal Cancer

JAMA , Volume 309 (24) – Jun 26, 2013

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Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2013.6600
pmid
23800937
Publisher site
See Article on Publisher Site

Abstract

Editorials represent the opinions EDITORIAL of the authors and JAMA and not those of the American Medical Association. Differential Effects of Aspirin Before and After Diagnosis of Colorectal Cancer subtypes of colorectal cancer aspirin most effectively pre- Boris Pasche, MD, PhD vents both before and after diagnosis. In 2009, Chan et al demonstrated that regular aspirin intake after diagnosis of LTHOUGH MORBIDITY AND MORTALITY FROM COLO- colorectal cancer in patients whose primary tumors over- rectal cancer have steadily decreased over the past expressed PTGS2 as assessed by immunohistochemistry was 3 decades, colorectal cancer remains the third most associated with a 60% decreased risk of colorectal cancer– Acommon form of cancer and the third most com- specific mortality. In contrast, there was no association be- mon cause of cancer death in the United States. Early dis- tween aspirin use and lower mortality risk among patients ease detection through increases in screening that can iden- whose primary tumors had weak or absent PTGS2 expres- tify and allow removal of precancerous polyps is thought sion. In 2012, Liao et al tested the hypothesis that muta- to be the major reason for the decrease in colorectal cancer tions in the PIK3CA gene, one

Journal

JAMAAmerican Medical Association

Published: Jun 26, 2013

References