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Diagnostic Validity of 12-Hour Integrated Concentration of Growth Hormone

Diagnostic Validity of 12-Hour Integrated Concentration of Growth Hormone Abstract • We tested the hypothesis that integrated concentration of human growth hormone (ICGH) during the 12-hour nighttime (8PM to 8 AM) period is closely correlated with the 24-hour integrated concentration and would be as useful for diagnostic purposes. We determined hourly ICGH during 24 hours in 67 children and calculated the 12- and 24-hour values. Nineteen children had normal stature, 13 had classic growth hormone deficiency, four had growth hormone neurosecretory dysfunction, 23 had short stature but no hormonal abnormality could be diagnosed, and eight had miscellaneous disorders. There was a close correlation between the 12- and the 24-hour ICGH. For diagnostic purposes, 12-hour nighttime ICGH is as useful as 24-hour ICGH. Use of the shorter test for determination of physiologic growth hormone secretion will save the patients time, expense, and blood volume. (AJDC 1987;141:553-555) References 1. Spiliotis BE, August GP, Hung W, et al: Growth hormone neurosecretory dysfunction: A treatable cause of short stature . JAMA 1984;251: 2223-2230.Crossref 2. Finkelstein JW, Roffwang HP, Boyar RM, et al: Age related change in the 24-hour spontaneous secretion of growth hormone . J Clin Endocrinol Metab 1972;35:665-670.Crossref 3. Miller JD, Tannenbaum GS, Colle E, et al: Daytime pulsatile growth hormone secretion during childhood and adolescence . J Clin Endocrinol Metab 1982;55:989-994.Crossref 4. Kowarski AA, Thompson RG, Migeon CJ, et al: Determination of integrated plasma concentrations and true secretion rates of human growth hormone . J Clin Endocrinol Metab 1971;32: 356-360.Crossref 5. Plotnick LP, Thompson RG, Kowarski AA, et al: Circadian variation of integrated concentration of growth hormone in children and adults . J Clin Endocrinol Metab 1975;40:240-247.Crossref 6. Zadik Z, Chalew SA, McCarter RJ, et al: The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals . J Clin Endocrinol Metab 1985;60: 513-516.Crossref 7. Plotnick LP, Lee PA, Migeon CJ, et al: Comparison of physiological and pharmacological tests of growth hormone function in children with short stature . J Clin Endocrinol Metab 1979;48: 811-815.Crossref 8. Hendmarsh PE, Smith PJ, Taylor BJ, et al: Comparison between a physiological and a pharmacological stimulus of growth hormone secretion: Response to stage IV sleep and insulininduced hypoglycaemia . Lancet 1985;2:1033-1035.Crossref 9. Zadik Z, Chalew SA, Raiti S, et al: Do short children secrete insufficient growth hormone? Pediatrics 1985;76:355-360. 10. Illig R, Stahl M, Henrichs I: Growth hormone release during slow wave sleep: Comparison with insulin and arginine provocation in children with small stature . Helv Paediatr Acta 1971;26:665-672. 11. Howse PM, Rayner PHW, Williams JW, et al: Nyctohemeral secretion of growth hormone in normal children of short stature and in children with hypopituitarism and intrauterine growth retardation . Clin Endocrinol 1977;6:347-359.Crossref 12. Honda Y, Takahaski K, Takahaski S, et al: Growth hormone secretion during nocturnal sleep in normal subjects . J Clin Endocrinol Metab 1969;29:20-29.Crossref 13. Bercu BB, Shulman D, Root AW, et al: Growth hormone (GH) provocative testing frequently does not reflect endogenous GH secretion . J Clin Endocrinol Metab 1986;63:709-716.Crossref 14. Meistas MT, Foster GV, Margolis S, et al: Integrated concentrations of growth hormone, insulin, C peptide and prolactin in human obesity . Metabolism 1982;31:1224-1228.Crossref 15. Meyer WJ, Richards GE, Cavallo A, et al: Growth hormone and cortisol diurnal rhythm and responsiveness to provocative stimuli in children with major and minor depression , abstracted. Pediatr Res 1986;20:217. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Diagnostic Validity of 12-Hour Integrated Concentration of Growth Hormone

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460050095039
Publisher site
See Article on Publisher Site

Abstract

Abstract • We tested the hypothesis that integrated concentration of human growth hormone (ICGH) during the 12-hour nighttime (8PM to 8 AM) period is closely correlated with the 24-hour integrated concentration and would be as useful for diagnostic purposes. We determined hourly ICGH during 24 hours in 67 children and calculated the 12- and 24-hour values. Nineteen children had normal stature, 13 had classic growth hormone deficiency, four had growth hormone neurosecretory dysfunction, 23 had short stature but no hormonal abnormality could be diagnosed, and eight had miscellaneous disorders. There was a close correlation between the 12- and the 24-hour ICGH. For diagnostic purposes, 12-hour nighttime ICGH is as useful as 24-hour ICGH. Use of the shorter test for determination of physiologic growth hormone secretion will save the patients time, expense, and blood volume. (AJDC 1987;141:553-555) References 1. Spiliotis BE, August GP, Hung W, et al: Growth hormone neurosecretory dysfunction: A treatable cause of short stature . JAMA 1984;251: 2223-2230.Crossref 2. Finkelstein JW, Roffwang HP, Boyar RM, et al: Age related change in the 24-hour spontaneous secretion of growth hormone . J Clin Endocrinol Metab 1972;35:665-670.Crossref 3. Miller JD, Tannenbaum GS, Colle E, et al: Daytime pulsatile growth hormone secretion during childhood and adolescence . J Clin Endocrinol Metab 1982;55:989-994.Crossref 4. Kowarski AA, Thompson RG, Migeon CJ, et al: Determination of integrated plasma concentrations and true secretion rates of human growth hormone . J Clin Endocrinol Metab 1971;32: 356-360.Crossref 5. Plotnick LP, Thompson RG, Kowarski AA, et al: Circadian variation of integrated concentration of growth hormone in children and adults . J Clin Endocrinol Metab 1975;40:240-247.Crossref 6. Zadik Z, Chalew SA, McCarter RJ, et al: The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals . J Clin Endocrinol Metab 1985;60: 513-516.Crossref 7. Plotnick LP, Lee PA, Migeon CJ, et al: Comparison of physiological and pharmacological tests of growth hormone function in children with short stature . J Clin Endocrinol Metab 1979;48: 811-815.Crossref 8. Hendmarsh PE, Smith PJ, Taylor BJ, et al: Comparison between a physiological and a pharmacological stimulus of growth hormone secretion: Response to stage IV sleep and insulininduced hypoglycaemia . Lancet 1985;2:1033-1035.Crossref 9. Zadik Z, Chalew SA, Raiti S, et al: Do short children secrete insufficient growth hormone? Pediatrics 1985;76:355-360. 10. Illig R, Stahl M, Henrichs I: Growth hormone release during slow wave sleep: Comparison with insulin and arginine provocation in children with small stature . Helv Paediatr Acta 1971;26:665-672. 11. Howse PM, Rayner PHW, Williams JW, et al: Nyctohemeral secretion of growth hormone in normal children of short stature and in children with hypopituitarism and intrauterine growth retardation . Clin Endocrinol 1977;6:347-359.Crossref 12. Honda Y, Takahaski K, Takahaski S, et al: Growth hormone secretion during nocturnal sleep in normal subjects . J Clin Endocrinol Metab 1969;29:20-29.Crossref 13. Bercu BB, Shulman D, Root AW, et al: Growth hormone (GH) provocative testing frequently does not reflect endogenous GH secretion . J Clin Endocrinol Metab 1986;63:709-716.Crossref 14. Meistas MT, Foster GV, Margolis S, et al: Integrated concentrations of growth hormone, insulin, C peptide and prolactin in human obesity . Metabolism 1982;31:1224-1228.Crossref 15. Meyer WJ, Richards GE, Cavallo A, et al: Growth hormone and cortisol diurnal rhythm and responsiveness to provocative stimuli in children with major and minor depression , abstracted. Pediatr Res 1986;20:217.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1987

References