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Diagnostic Accuracy of Virtual Pathology vs Traditional Microscopy in a Large Dermatopathology Study

Diagnostic Accuracy of Virtual Pathology vs Traditional Microscopy in a Large Dermatopathology Study Key PointsQuestionIs diagnosis from whole-slide images (WSI) noninferior to diagnosis from glass slides for cutaneous specimens? FindingsThis large retrospective study of 499 representative dermatopathology cases found 94% intraobserver concordance between WSI and traditional microscopy (TM). Diagnosis from WSI was found statistically noninferior to diagnosis from glass slides compared with ground truth consensus diagnosis. MeaningIn most cases, we found diagnosis from WSI noninferior to TM. The WSI method approached, but did not achieve, noninferiority for the subset of melanocytic lesions. Discordance in TM diagnosis of this challenging group is broadly recognized and further investigation of melanocytic neoplasms is recommended. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/jamadermatol.2017.3284
pmid
29049424
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionIs diagnosis from whole-slide images (WSI) noninferior to diagnosis from glass slides for cutaneous specimens? FindingsThis large retrospective study of 499 representative dermatopathology cases found 94% intraobserver concordance between WSI and traditional microscopy (TM). Diagnosis from WSI was found statistically noninferior to diagnosis from glass slides compared with ground truth consensus diagnosis. MeaningIn most cases, we found diagnosis from WSI noninferior to TM. The WSI method approached, but did not achieve, noninferiority for the subset of melanocytic lesions. Discordance in TM diagnosis of this challenging group is broadly recognized and further investigation of melanocytic neoplasms is recommended.

Journal

JAMA DermatologyAmerican Medical Association

Published: Dec 11, 2017

References