Key PointsQuestionIs diagnosis from whole-slide images (WSI) noninferior to diagnosis from glass slides for cutaneous specimens? FindingsThis large retrospective study of 499 representative dermatopathology cases found 94% intraobserver concordance between WSI and traditional microscopy (TM). Diagnosis from WSI was found statistically noninferior to diagnosis from glass slides compared with ground truth consensus diagnosis. MeaningIn most cases, we found diagnosis from WSI noninferior to TM. The WSI method approached, but did not achieve, noninferiority for the subset of melanocytic lesions. Discordance in TM diagnosis of this challenging group is broadly recognized and further investigation of melanocytic neoplasms is recommended.
JAMA Dermatology – American Medical Association
Published: Dec 11, 2017