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Diagnostic Accuracy of Computed Tomographic Colonography for the Detection of Advanced Neoplasia in Individuals at Increased Risk of Colorectal Cancer

Diagnostic Accuracy of Computed Tomographic Colonography for the Detection of Advanced Neoplasia... ORIGINAL CONTRIBUTION Diagnostic Accuracy of Computed Tomographic Colonography for the Detection of Advanced Neoplasia in Individuals at Increased Risk of Colorectal Cancer Daniele Regge, MD Context Computed tomographic (CT) colonography has been recognized as an al- Cristiana Laudi, MD ternative for colorectal cancer (CRC) screening in average-risk individuals, but less in- formation is available on its performance in individuals at increased risk of CRC. Giovanni Galatola, MD Objective To assess the accuracy of CT colonography in detecting advanced colo- Patrizia Della Monica, PhD rectal neoplasia in asymptomatic individuals at increased risk of CRC using unblinded Luigina Bonelli, MD colonoscopy as the reference standard. Giuseppe Angelelli, MD Design, Setting, and Participants This was a multicenter, cross-sectional study. Individuals at increased risk of CRC due to either family history of advanced neoplasia Roberto Asnaghi, MD in first-degree relatives, personal history of colorectal adenomas, or positive results Brunella Barbaro, MD from fecal occult blood tests (FOBTs) were recruited in 11 Italian centers and 1 Bel- Carlo Bartolozzi, MD gian center between December 2004 and May 2007. Each participant underwent CT colonography followed by colonoscopy on the same day. Didier Bielen, MD Main Outcome Measures Sensitivity and specificity of CT colonography in de- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2009.832
pmid
19531785
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Diagnostic Accuracy of Computed Tomographic Colonography for the Detection of Advanced Neoplasia in Individuals at Increased Risk of Colorectal Cancer Daniele Regge, MD Context Computed tomographic (CT) colonography has been recognized as an al- Cristiana Laudi, MD ternative for colorectal cancer (CRC) screening in average-risk individuals, but less in- formation is available on its performance in individuals at increased risk of CRC. Giovanni Galatola, MD Objective To assess the accuracy of CT colonography in detecting advanced colo- Patrizia Della Monica, PhD rectal neoplasia in asymptomatic individuals at increased risk of CRC using unblinded Luigina Bonelli, MD colonoscopy as the reference standard. Giuseppe Angelelli, MD Design, Setting, and Participants This was a multicenter, cross-sectional study. Individuals at increased risk of CRC due to either family history of advanced neoplasia Roberto Asnaghi, MD in first-degree relatives, personal history of colorectal adenomas, or positive results Brunella Barbaro, MD from fecal occult blood tests (FOBTs) were recruited in 11 Italian centers and 1 Bel- Carlo Bartolozzi, MD gian center between December 2004 and May 2007. Each participant underwent CT colonography followed by colonoscopy on the same day. Didier Bielen, MD Main Outcome Measures Sensitivity and specificity of CT colonography in de-

Journal

JAMAAmerican Medical Association

Published: Jun 17, 2009

References