HISTORY OF NEUROLOGY: SEMINAL CITATION Vladimir Skljarevski, MD; Alberto Lledo, MD, PhD his essay focuses on 3 issues pertinent to a historical discussion of diabetic neuropa- thies: ancient observations, 18th- and 19th-century advances, and the discovery of in- sulin. Given that the underlying biochemical mechanisms of diabetic neuropathy re- T main poorly understood and that currently used therapies, although seemingly less bizarre than those of the past, are not substantially more effective, the final chapter on the history of diabetic neuropathy remains to be written. THE ANCIENT PERIOD ropathy came from the Indian physician 3,4 Susruta. In the 5th century AD, he wrote In 1862, egyptologist Georg Ebers found the following in Sanskrit: “Patients com- a papyrus dating from about 1550 BC that plain of profound thirst, burning in the contained a description of various dis- palms and soles, body (skin) becomes unc- eases and their cures (Ebers papyrus). It tuous and slimy and feel heavy, urine is made note of a polyuric state resembling sweet, bad in smell and white in color. diabetes that was to be treated with a 4-day Complications include diarrhea, consti- 4(p506-507) course of a liquid extract of bones, wheat, pation and fainting.” Of
JAMA Neurology – American Medical Association
Published: Oct 1, 2006
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