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Dexamethasone and Risk of Nausea and Vomiting and Postoperative Bleeding After Tonsillectomy in Children

Dexamethasone and Risk of Nausea and Vomiting and Postoperative Bleeding After Tonsillectomy in... PRELIMINARY COMMUNICATION Dexamethasone and Risk of Nausea and Vomiting and Postoperative Bleeding After Tonsillectomy in Children A Randomized Trial Christoph Czarnetzki, MD, MBA Context Dexamethasone is widely used to prevent postoperative nausea and vom- Nadia Elia, MD, MSc iting (PONV) in pediatric tonsillectomy. Christopher Lysakowski, MD Objective To assess whether dexamethasone dose-dependently reduces the risk of PONV at 24 hours after tonsillectomy. Lionel Dumont, MD Design, Setting, and Patients Randomized placebo-controlled trial conducted among Basile N. Landis, MD 215 children undergoing elective tonsillectomy at a major public teaching hospital in Roland Giger, MD Switzerland from February 2005 to December 2007. Pavel Dulguerov, MD Interventions Children were randomly assigned to receive dexamethasone (0.05, 0.15, or 0.5 mg/kg) or placebo intravenously after induction of anesthesia. Acetami- Jules Desmeules, MD nophen-codeine and ibuprofen were given as postoperative analgesia. Follow-up con- Martin R. Tramèr, MD, DPhil tinued until the 10th postoperative day. Main Outcome Measures The primary end point was prevention of PONV at 24 ONSILLECTOMY IS ONE OF THE hours; secondary end points were decrease in the need for ibuprofen at 24 hours and most frequently performed sur- evaluation of adverse effects. gical procedures in children. In Results At 24 hours, 24 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Dexamethasone and Risk of Nausea and Vomiting and Postoperative Bleeding After Tonsillectomy in Children

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References (45)

Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2008.794
pmid
19066382
Publisher site
See Article on Publisher Site

Abstract

PRELIMINARY COMMUNICATION Dexamethasone and Risk of Nausea and Vomiting and Postoperative Bleeding After Tonsillectomy in Children A Randomized Trial Christoph Czarnetzki, MD, MBA Context Dexamethasone is widely used to prevent postoperative nausea and vom- Nadia Elia, MD, MSc iting (PONV) in pediatric tonsillectomy. Christopher Lysakowski, MD Objective To assess whether dexamethasone dose-dependently reduces the risk of PONV at 24 hours after tonsillectomy. Lionel Dumont, MD Design, Setting, and Patients Randomized placebo-controlled trial conducted among Basile N. Landis, MD 215 children undergoing elective tonsillectomy at a major public teaching hospital in Roland Giger, MD Switzerland from February 2005 to December 2007. Pavel Dulguerov, MD Interventions Children were randomly assigned to receive dexamethasone (0.05, 0.15, or 0.5 mg/kg) or placebo intravenously after induction of anesthesia. Acetami- Jules Desmeules, MD nophen-codeine and ibuprofen were given as postoperative analgesia. Follow-up con- Martin R. Tramèr, MD, DPhil tinued until the 10th postoperative day. Main Outcome Measures The primary end point was prevention of PONV at 24 ONSILLECTOMY IS ONE OF THE hours; secondary end points were decrease in the need for ibuprofen at 24 hours and most frequently performed sur- evaluation of adverse effects. gical procedures in children. In Results At 24 hours, 24

Journal

JAMA – American Medical Association

Published: Dec 10, 2008

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