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DEVELOPMENT OF THE FETAL LUNG

DEVELOPMENT OF THE FETAL LUNG For a number of years we have been struck by the absence of truly pathologic lesions as a cause of death among many of the immature infants born in the Pennsylvania Hospital. Many of these infants appeared to have died of respiratory failure, as evidenced by cyanosis and gasping respirations in the presence of seemingly normal cardiac function. In fact, it was usual for the heart to continue beating even after respirations had ceased. Numerous embryologic studies on the development of the fetal lung and the lining of the alveoli have been made; yet in the literature there has been little discussion of the clinical significance of the results of such studies. Although death in the premature infant is undoubtedly caused by a complex mechanism which includes anatomic and metabolic dysfunction of numerous organs, it seemed desirable to make an anatomic study of the fetal lung to determine what bearing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1941 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1941.02000110021003
Publisher site
See Article on Publisher Site

Abstract

For a number of years we have been struck by the absence of truly pathologic lesions as a cause of death among many of the immature infants born in the Pennsylvania Hospital. Many of these infants appeared to have died of respiratory failure, as evidenced by cyanosis and gasping respirations in the presence of seemingly normal cardiac function. In fact, it was usual for the heart to continue beating even after respirations had ceased. Numerous embryologic studies on the development of the fetal lung and the lining of the alveoli have been made; yet in the literature there has been little discussion of the clinical significance of the results of such studies. Although death in the premature infant is undoubtedly caused by a complex mechanism which includes anatomic and metabolic dysfunction of numerous organs, it seemed desirable to make an anatomic study of the fetal lung to determine what bearing

Journal

American journal of diseases of childrenAmerican Medical Association

Published: May 1, 1941

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