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Development of Novel Medications for Use in the Treatment of Obesity in Children Will Be Directed by Delineating Controls of Energy Homeostasis

Development of Novel Medications for Use in the Treatment of Obesity in Children Will Be Directed... EDITORIAL Development of Novel Medications for Use in the Treatment of Obesity in Children Will Be Directed by Delineating Controls of Energy Homeostasis HIS ISSUE of the ARCHIVES highlights the current creased appreciation of the controls involved in appe- pandemic of obesity, and its resultant compli- tite, sensations of satiety, and energy expenditure or T cations, in children and adolescents. What is to thermogenesis. Substantial advances have been made in be done about this alarming situation? Clearly, there is the past decade employing mouse models of obesity. In- no single easy answer to a complex matter that likely has terested readers are referred to several recent, compre- 4,5 multiple etiologic risk factors. hensive reviews of this rapidly evolving discipline. Future attention must be paid to both the preven- The identification of genes involved in the control tion and treatment of childhood obesity. However, as many of obesity in mice has led to discoveries of human ho- will know from personal experience, it is not clear what mologues. For instance, mutations in the leptin gene and are the most appropriate interventions. Even very small leptin receptor have been identified as a rare cause of discrepancies in energy intake will result, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Development of Novel Medications for Use in the Treatment of Obesity in Children Will Be Directed by Delineating Controls of Energy Homeostasis

JAMA Pediatrics , Volume 157 (8) – Aug 1, 2003

Development of Novel Medications for Use in the Treatment of Obesity in Children Will Be Directed by Delineating Controls of Energy Homeostasis

Abstract

EDITORIAL Development of Novel Medications for Use in the Treatment of Obesity in Children Will Be Directed by Delineating Controls of Energy Homeostasis HIS ISSUE of the ARCHIVES highlights the current creased appreciation of the controls involved in appe- pandemic of obesity, and its resultant compli- tite, sensations of satiety, and energy expenditure or T cations, in children and adolescents. What is to thermogenesis. Substantial advances have been made in be done about this alarming...
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Publisher
American Medical Association
Copyright
Copyright 2003 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/archpedi.157.8.721
pmid
12912773
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL Development of Novel Medications for Use in the Treatment of Obesity in Children Will Be Directed by Delineating Controls of Energy Homeostasis HIS ISSUE of the ARCHIVES highlights the current creased appreciation of the controls involved in appe- pandemic of obesity, and its resultant compli- tite, sensations of satiety, and energy expenditure or T cations, in children and adolescents. What is to thermogenesis. Substantial advances have been made in be done about this alarming situation? Clearly, there is the past decade employing mouse models of obesity. In- no single easy answer to a complex matter that likely has terested readers are referred to several recent, compre- 4,5 multiple etiologic risk factors. hensive reviews of this rapidly evolving discipline. Future attention must be paid to both the preven- The identification of genes involved in the control tion and treatment of childhood obesity. However, as many of obesity in mice has led to discoveries of human ho- will know from personal experience, it is not clear what mologues. For instance, mutations in the leptin gene and are the most appropriate interventions. Even very small leptin receptor have been identified as a rare cause of discrepancies in energy intake will result,

Journal

JAMA PediatricsAmerican Medical Association

Published: Aug 1, 2003

References