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Determining Chances for Survival in Intrahepatic Cholangiocarcinoma

Determining Chances for Survival in Intrahepatic Cholangiocarcinoma Research Original Investigation Long-term Survival After Liver Resection for Cancer Invited Commentary Determining Chances for Survival in Intrahepatic Cholangiocarcinoma Jake E. Krige, MSc, FRCS, FCS(SA); Delawir Kahn, ChM, FCS(SA) As a patient might ask, “Doctor, now that you have success- when survival reaches a plateau after 2 to 3 years with no fully removed my liver cancer, what are my chances?” substantial increase in mortality thereafter. In contrast, “We are very pleased that you have recovered so well from while the greatest risk to survival is in the first few years for the operation but, unfortunately, as we have discussed previ- patients with more aggressive tumors, such as pancreas, ously, this is a serious cancer and we know that as many as two- lung, or breast cancer, the survivors still require sustained thirds of patients die within the first 2 years. However, if you and prolonged surveillance, extending to 10 years and are alive after 3 years, your chances of long-term survival are beyond because of inexorable attrition rates. The continued good,” might be a physician’s response. decline in overall survival in this high-risk cohort compared The latter part of this fictitious conversation seldom oc- with a similarly aged http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Surgery American Medical Association

Determining Chances for Survival in Intrahepatic Cholangiocarcinoma

Krige, Jake E.; Kahn, Delawir
JAMA Surgery , Volume 150 (6) – Jun 1, 2015
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Determining Chances for Survival in Intrahepatic Cholangiocarcinoma

Abstract

Research Original Investigation Long-term Survival After Liver Resection for Cancer Invited Commentary Determining Chances for Survival in Intrahepatic Cholangiocarcinoma Jake E. Krige, MSc, FRCS, FCS(SA); Delawir Kahn, ChM, FCS(SA) As a patient might ask, “Doctor, now that you have success- when survival reaches a plateau after 2 to 3 years with no fully removed my liver cancer, what are my chances?” substantial increase in mortality thereafter. In contrast, “We are very...
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Publisher
American Medical Association
Copyright
Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6254
eISSN
2168-6262
DOI
10.1001/jamasurg.2015.0236
pmid
25831124
Publisher site
See Article on Publisher Site

Abstract

Research Original Investigation Long-term Survival After Liver Resection for Cancer Invited Commentary Determining Chances for Survival in Intrahepatic Cholangiocarcinoma Jake E. Krige, MSc, FRCS, FCS(SA); Delawir Kahn, ChM, FCS(SA) As a patient might ask, “Doctor, now that you have success- when survival reaches a plateau after 2 to 3 years with no fully removed my liver cancer, what are my chances?” substantial increase in mortality thereafter. In contrast, “We are very pleased that you have recovered so well from while the greatest risk to survival is in the first few years for the operation but, unfortunately, as we have discussed previ- patients with more aggressive tumors, such as pancreas, ously, this is a serious cancer and we know that as many as two- lung, or breast cancer, the survivors still require sustained thirds of patients die within the first 2 years. However, if you and prolonged surveillance, extending to 10 years and are alive after 3 years, your chances of long-term survival are beyond because of inexorable attrition rates. The continued good,” might be a physician’s response. decline in overall survival in this high-risk cohort compared The latter part of this fictitious conversation seldom oc- with a similarly aged

Journal

JAMA Surgery – American Medical Association

Published: Jun 1, 2015

References

  • Conditional probability of long-term survival after liver resection for intrahepatic cholangiocarcinoma: a multi-institutional analysis of 535 patients [published online April 1, 2015].
    Spolverato, G; Kim, Y; Ejaz, A
  • Treatment and prognosis for patients with intrahepatic cholangiocarcinoma: systematic review and meta-analysis.
    Mavros, MN; Economopoulos, KP; Alexiou, VG; Pawlik, TM
  • Intrahepatic cholangiocarcinoma: management options and emerging therapies.
    Dodson, RM; Weiss, MJ; Cosgrove, D

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