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Determination of Pseudofacility in the Eye of the Rhesus Monkey

Determination of Pseudofacility in the Eye of the Rhesus Monkey Abstract The possibility that net inflow into the eye may be altered by changes in the intraocular pressure has been discussed previously.1 Net inflow may be subdivided into secretion and ultrafiltration minus colloid reabsorption. Secretion, as defined by Kinsey, is unaltered by changes in intraocular pressure.2 Ultrafiltration, however, which is dependent on the difference between capillary pressure and intraocular pressure for its driving force, should be reduced by a rise in intraocular pressure. Hence, net flow into the eye should decrease with increasing intraocular pressure. The mathematical basis for this concept was presented in 1963 by Bárány who used the term "pseudofacility" for the change in net inflow which occurred for a corresponding change in the intraocular pressure.3 Pseudofacility is an appropriate term for several reasons. First, it has the same units as total facility,* that is μl min-1 mm Hg-1. Second, it represents some unknown References 1. In the remainder of this paper, the term "total facility" will be used in lieu of the term "facility of outflow." 2. Ventilatory rate was determined by the method of Kleinman and Radford. 3. Steady state was assumed to be present if the rate of change of Pi was less than 0.5 cm H2O/3 min. 4. After Bárány. 5. Grant, W.M.: in Newell, F. W. (ed.): Glaucoma, Tr. of the Third Conference , New York: 1959, Josiah Macy, Jr. Foundation, pp 19-20. 6. Kinsey, V.E.: in Prince, M. H. (ed.): The Rabbit in Eye Research , Springfield: Charles C Thomas, 1964, pp 240-241. 7. Bárány, E.H.: A Mathematical Formulation of Intraocular Pressure as Dependent of Secretion, Ultrafiltration, Bulk Outflow, and Osmotic Reabsorption of Fluid , Invest Ophthal 2:584, 1963. 8. Sears, M.L.: Miosis and Intraocular Pressure Changes During Manometry , Arch Ophthal 63:707, 1960.Crossref 9. Bárány, E.H.: The Mode of Action of Pilocarpine on Outflow Resistance in the Eye of a Primate (Cercopithecus ethiops) , Invest Ophthal 1:712, 1961. 10. Brubaker, R.F.: The Measurement of Episcleral Venous Pressure: A Comparison of Three Methods, submitted for publication. 11. Sears, M.L.: Outflow Resistance of the Rabbit Eye: Technique and Effects of Acetazolamide , Arch Ophthal 64:823, 1960.Crossref 12. Langham, M.E.: Steady-state Pressure Flow Relationships in the Living and Dead Eye of the Cat , Amer J Ophthal 50:280 ( (pt 2) ) 1960. 13. Armaly, M.: The Effect of Intraocular Pressure on Outflow Facility , Arch Ophthal 64:125, 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Determination of Pseudofacility in the Eye of the Rhesus Monkey

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1966.00970050695022
Publisher site
See Article on Publisher Site

Abstract

Abstract The possibility that net inflow into the eye may be altered by changes in the intraocular pressure has been discussed previously.1 Net inflow may be subdivided into secretion and ultrafiltration minus colloid reabsorption. Secretion, as defined by Kinsey, is unaltered by changes in intraocular pressure.2 Ultrafiltration, however, which is dependent on the difference between capillary pressure and intraocular pressure for its driving force, should be reduced by a rise in intraocular pressure. Hence, net flow into the eye should decrease with increasing intraocular pressure. The mathematical basis for this concept was presented in 1963 by Bárány who used the term "pseudofacility" for the change in net inflow which occurred for a corresponding change in the intraocular pressure.3 Pseudofacility is an appropriate term for several reasons. First, it has the same units as total facility,* that is μl min-1 mm Hg-1. Second, it represents some unknown References 1. In the remainder of this paper, the term "total facility" will be used in lieu of the term "facility of outflow." 2. Ventilatory rate was determined by the method of Kleinman and Radford. 3. Steady state was assumed to be present if the rate of change of Pi was less than 0.5 cm H2O/3 min. 4. After Bárány. 5. Grant, W.M.: in Newell, F. W. (ed.): Glaucoma, Tr. of the Third Conference , New York: 1959, Josiah Macy, Jr. Foundation, pp 19-20. 6. Kinsey, V.E.: in Prince, M. H. (ed.): The Rabbit in Eye Research , Springfield: Charles C Thomas, 1964, pp 240-241. 7. Bárány, E.H.: A Mathematical Formulation of Intraocular Pressure as Dependent of Secretion, Ultrafiltration, Bulk Outflow, and Osmotic Reabsorption of Fluid , Invest Ophthal 2:584, 1963. 8. Sears, M.L.: Miosis and Intraocular Pressure Changes During Manometry , Arch Ophthal 63:707, 1960.Crossref 9. Bárány, E.H.: The Mode of Action of Pilocarpine on Outflow Resistance in the Eye of a Primate (Cercopithecus ethiops) , Invest Ophthal 1:712, 1961. 10. Brubaker, R.F.: The Measurement of Episcleral Venous Pressure: A Comparison of Three Methods, submitted for publication. 11. Sears, M.L.: Outflow Resistance of the Rabbit Eye: Technique and Effects of Acetazolamide , Arch Ophthal 64:823, 1960.Crossref 12. Langham, M.E.: Steady-state Pressure Flow Relationships in the Living and Dead Eye of the Cat , Amer J Ophthal 50:280 ( (pt 2) ) 1960. 13. Armaly, M.: The Effect of Intraocular Pressure on Outflow Facility , Arch Ophthal 64:125, 1960.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1966

References