ORIGINAL ARTICLE Detection of Oral Squamous Cell Carcinoma and Cervical Lymph Node Metastasis Using Activatable Near-Infrared Fluorescence Agents Stijn Keereweer, MD; J. Sven D. Mieog, MD; Isabel M. Mol, BA; Pieter B. A. A. Van Driel, BA; Thomas J. A. Snoeks, MSc; Robert J. Baatenburg de Jong, MD, PhD; Alexander L. Vahrmeijer, MD, PhD; Jeroen D. F. Kerrebijn, MD, PhD; Clemens W. G. M. Lo¨wik, PhD Objective: To assess the feasibility of optical imaging determined on histologic sections of the tongue and cer- using activatable near-infrared fluorescence (NIRF) agents vical lymph nodes after resection at necropsy. to detect oral cancer and cervical lymph node metasta- sis in vivo. Main Outcome Measure: Fluorescence signals. Design: In vivo study. Results: Thefluorescencesignalsintonguetumorandcer- vical lymph node metastases were significantly higher than Setting: University medical center. thoseincontrolanimals.Themean(SD)TBRofProSense680 in the tongue was 15.8 (8.1) and in the lymph nodes was Subjects: Female nude mice aged 4 to 6 weeks. 11.8 (3.6). For MMPSense680, the mean (SD) TBR in the tonguewas18.6(9.4)andinthelymphnodeswas10.5(4.0). Intervention: Luciferase-expressing OSC-19-luc cells were injected into the tongues of nude mice. A control Conclusions: Oral cancer and cervical lymph node me- group of nude mice was injected in the tongue with a tastases can
JAMA Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Jun 1, 2011
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera