Abstract IN RECENT studies, we have found that measurement of the uptake of radioactive phosphorus in tumor tissue can be applied as a valuable test to aid in the diagnosis of intraocular tumors in cases in which the clinical ophthalmologic evidence as to the cause of retinal separation is not conclusive. This test to date has been used in eight cases of possible tumor and has proved fairly successful. Because of the definite, although unexploited, value of the test, and because of the relatively small number of tumors which are seen, it was decided that a preliminary report should be submitted at this time. BACKGROUND The use of radioactive material for the localization of tumors has assumed increasing importance in recent years. In 1946, Low-Beer1 proposed the use of radioactive phosphorus in diagnosis and localization of breast tumors. Moore and associates2 noted a consistent affinity of brain tumors for References 1. Low-Beer, B. V. A.: Surface Measurements of Radioactive Phosphorus in Breast Tumors as Possible Diagnostic Method , Science 104:399 ( (Oct. 25) ) 1946.Crossref 2. Moore, G. E.: (a) Fluorescein as an Agent in the Differentiation of Normal and Malignant Tissue , Science 106:130-131 ( (Aug. 8) ) 1947Crossref 3. (b) Use of Radioactive Diiodofluorescein in the Diagnosis and Localization of Brain Tumors , Moore Science 107:569-571 ( (May 28) ) 1948.Crossref 4. (c) Moore, G. E.; Hunter, G. W., and Hubbard, T. B.: Clinical and Experimental Studies of Fluorescein Dyes, with Special Reference to Their Use for the Diagnosis of Central Nervous System Tumors , Ann. Surg. 130:637-642 ( (Oct.) ) 1949.Crossref 5. Woolsey, R. D., and Thoma, G. E.: Localization of Intracranial Neoplasms with Radioactive Diiodofluorescein , J. Missouri M. A. 47:885-889 ( (Dec.) ) 1950. 6. Selverstone, B.; Solomon, A. K., and Sweet, W. H.: Localization of Brain Tumors by Means of Radioactive Phosphorus , J. A. M. A. 140:277-278 ( (May 21) ) 1949.Crossref 7. Selverstone, B.; Sweet, W. H., and Robinson, C. V.: Clinical Use of Radioactive Phosphorus in the Surgery of Brain Tumors , Ann. Surg. 130:643-651 ( (Oct.) ) 1949.Crossref 8. Marshak, A.: P32 Uptake by Nuclei , J. Gen. Physiol. 25:275-291 ( (Nov.) ) 1941.Crossref 9. Tuttle, L. W.; Erf, L. A., and Lawrence, J. H.: Studies on Neoplasms with the Aid of Radioactive Phosphorus: II. Phosphorus Metabolism of the Nucleoprotein, Phospholipid and Acid Soluble Fractions of Normal and Leukemic Mice , J. Clin. Invest. 20:57-61 ( (Jan.) ) 1941.Crossref 10. Friedemann, U.: Blood-Brain Barrier , Physiol. Rev. 22:125-145 ( (April) ) 1942. 11. Model 222, made by Anton Electronic Laboratory, Inc., 1226-1238 Flushing Ave., Brooklyn 6. 12. A dose of 500 mc. of P32 is far below the level of radioactivity which might produce manifest injurious effects. This is relatively twice the generally accepted tolerance level, but the additional exposure is insignificant, The total radiation is less than that received during most diagnostic x-ray procedures.
A.M.A. Archives of Ophthalmology – American Medical Association
Published: Mar 1, 1952
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