Abstract To the Editor.— Human papillomavirus (HPV) type 16 (HPV-16) has been found in lesions of bowenoid papulosis, Bowen's disease, and cervical intraepithelial neoplasia, as well as anogenital carcinoma. Although bowenoid papulosis is well known to occur in patients who had been treated for cervical carcinoma,1 the progression of bowenoid papules themselves to invasive carcinoma is not well documented. In the present report we describe a woman with a previous history of treated carcinoma of the cervix who developed invasive carcinoma of Bowen's type, apparently arising from bowenoid papulosis on her perianal region, and regional lymph node metastasis; in both lesions of the invasive carcinoma and of bowenoid papulosis we found the presence of HPV-16 DNA. This case presents strong evidence for a causal relationship between HPV-16 and cancer derived from its precursor lesion. Report of a Case.— A 56-year-old woman was first seen by us in May 1986, with a complaint of a nodule of ten months' duration on the left side of her perianal References 1. Zachow KR, Ostrow RS, Bender M: Detection of human papillomavirus DNA in anogenital neoplasias . Nature 1982; 300:771-773.Crossref 2. Yoshikawa H, Mizuno M, Yoshiike K: Occurrence of human papillomavirus types 16 and 18 DNA in cervical carcinomas from Japan . Gann 1985;76:667-671.
Archives of Dermatology – American Medical Association
Published: Jun 1, 1988