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Detecting Acute Human Immunodeficiency Virus Infection Using 3 Different Screening Immunoassays and Nucleic Acid Amplification Testing for Human Immunodeficiency Virus RNA, 2006-2008

Detecting Acute Human Immunodeficiency Virus Infection Using 3 Different Screening Immunoassays... ORIGINAL INVESTIGATION Detecting Acute Human Immunodeficiency Virus Infection Using 3 Different Screening Immunoassays and Nucleic Acid Amplification Testing for Human Immunodeficiency Virus RNA, 2006-2008 Pragna Patel, MD, MPH; Duncan Mackellar, MA, MPH; Pat Simmons, BS; Apurva Uniyal, MA; Kathleen Gallagher, MPH; Berry Bennett, MPH; Timothy J. Sullivan, BS; Alexis Kowalski, MPH; Monica M. Parker, PhD; Marlene LaLota, MPH; Peter Kerndt, MD, MPH; Patrick S. Sullivan, DVM, PhD; for the Centers for Disease Control and Prevention Acute HIV Infection Study Group Background: The yield of nucleic acid amplification test- creasing HIV case detection by 8.2%. After a second- ing (NAAT) after routine screening for human immuno- generation rapid test, 6547 persons underwent NAAT; deficiency virus (HIV) antibody to detect acute HIV in- 7 AHIs were identified, increasing HIV case detection by fection (AHI) may vary with different HIV-antibody assays. 24.1%. After third-generation testing, 54 948 persons un- derwent NAAT; 12 AHI cases were identified, increas- Methods: From April 24, 2006, through March 28, 2008, ing HIV case detection by 1.4%. Overall, pooled NAAT patients underwent routine HIV-antibody screening using after negative third-generation test results detected 26 AHI a first-generation assay at 14 county sexually transmit- cases, increasing HIV case detection http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Detecting Acute Human Immunodeficiency Virus Infection Using 3 Different Screening Immunoassays and Nucleic Acid Amplification Testing for Human Immunodeficiency Virus RNA, 2006-2008

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Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinternmed.2009.445
pmid
20065201
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL INVESTIGATION Detecting Acute Human Immunodeficiency Virus Infection Using 3 Different Screening Immunoassays and Nucleic Acid Amplification Testing for Human Immunodeficiency Virus RNA, 2006-2008 Pragna Patel, MD, MPH; Duncan Mackellar, MA, MPH; Pat Simmons, BS; Apurva Uniyal, MA; Kathleen Gallagher, MPH; Berry Bennett, MPH; Timothy J. Sullivan, BS; Alexis Kowalski, MPH; Monica M. Parker, PhD; Marlene LaLota, MPH; Peter Kerndt, MD, MPH; Patrick S. Sullivan, DVM, PhD; for the Centers for Disease Control and Prevention Acute HIV Infection Study Group Background: The yield of nucleic acid amplification test- creasing HIV case detection by 8.2%. After a second- ing (NAAT) after routine screening for human immuno- generation rapid test, 6547 persons underwent NAAT; deficiency virus (HIV) antibody to detect acute HIV in- 7 AHIs were identified, increasing HIV case detection by fection (AHI) may vary with different HIV-antibody assays. 24.1%. After third-generation testing, 54 948 persons un- derwent NAAT; 12 AHI cases were identified, increas- Methods: From April 24, 2006, through March 28, 2008, ing HIV case detection by 1.4%. Overall, pooled NAAT patients underwent routine HIV-antibody screening using after negative third-generation test results detected 26 AHI a first-generation assay at 14 county sexually transmit- cases, increasing HIV case detection

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Jan 11, 2010

References