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"DESTRUCTION OF EPINEPHRINE IN THE BODY"

"DESTRUCTION OF EPINEPHRINE IN THE BODY" To the Editor: —The editorial comment on the destruction of epinephrine in the body (The Journal, September 21, p. 922) refers to the work of Markowitz and Mann and their conclusion, in harmony with that of Elliott, that epinephrine is destroyed in the thoracic nerve endings all over the body. Markowitz and Mann say: "Since epinephrine acts on thoracic autonomic endings all over the body, one would expect the most likely site for its destruction to be in these endings." This is a pure assumption. It is not supported by direct (or indirect) evidence. Nearly all alkaloids leave the blood stream rapidly, but their elimination by the kidneys or destruction by the liver is often a matter of hours or even days, and there is no necessary connection between the duration of a given action of an alkaloid and the period required for its elimination. One gains the impression from http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

"DESTRUCTION OF EPINEPHRINE IN THE BODY"

JAMA , Volume 93 (18) – Nov 2, 1929

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Publisher
American Medical Association
Copyright
Copyright © 1929 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1929.02710180055028
Publisher site
See Article on Publisher Site

Abstract

To the Editor: —The editorial comment on the destruction of epinephrine in the body (The Journal, September 21, p. 922) refers to the work of Markowitz and Mann and their conclusion, in harmony with that of Elliott, that epinephrine is destroyed in the thoracic nerve endings all over the body. Markowitz and Mann say: "Since epinephrine acts on thoracic autonomic endings all over the body, one would expect the most likely site for its destruction to be in these endings." This is a pure assumption. It is not supported by direct (or indirect) evidence. Nearly all alkaloids leave the blood stream rapidly, but their elimination by the kidneys or destruction by the liver is often a matter of hours or even days, and there is no necessary connection between the duration of a given action of an alkaloid and the period required for its elimination. One gains the impression from

Journal

JAMAAmerican Medical Association

Published: Nov 2, 1929

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