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Desiccation of Cornea and Conjunctiva After Sensory Denervation: Significance of Desiccation for Pathogenesis of Neuroparalytic Keratitis

Desiccation of Cornea and Conjunctiva After Sensory Denervation: Significance of Desiccation for... Abstract Sensory denervation of the eye is known to cause, in experimental animals as well as in man, corneal changes which subsequently may or may not develop into the full-blown picture of neuroparalytic keratitis. Numerous hypotheses have been advanced with regard to the pathogenesis of these initial lesions, which are naturally closely related to the respective authors' views as to the cause of neuroparalytic keratitis proper. The lesions which occur in experimental animals have been well described by Gaule,11 after whom they are commonly called "Gaule's Spots." Practically immediately after the gasserian ganglion or the ophthalmic division of the trigeminal nerve of the rabbit has been severed, an iridescent film is seen to spread over the corneal surface. Small, shallow pits develop which subsequently coalesce into a dry depression of the corneal center. By means of reflectography, Tagawa28 found the iridescence of the corneal surface to be caused by References 1. Arch. Ophthal. 64:34-43, 1960Crossref 2. Pharmacological pupil tests in the desensitized eyes reported elsewhere (1960) suggest that these are due to interruption of the trigeminal proper, not of sympathetic fibers. 3. Beetham, W. P.: Filamentary Keratitis , Trans. Amer. Ophthal. Soc. 33:413, 1935. 4. Behr, C.: Über die Grundlagen der Keratitis neuroparalytica: zugleich ein Beitrag zur Keratitis neuroparalytica nach Alkoholinjektionen ins Ganglion Gasseri , Z. Augenheilk. 62:1, 1927. 5. Dandy, W. E.: Trigeminal Neuralgia and Trigeminal Tic Douloureux , in Lewis' Practice of Surgery , Vol. 12, Hagerstown, Md., W. F. Prior Company, Inc., 1955, pp. 167-187. 6. de Haas, E. B. H.: Role of Sympathetic in Pathogenesis of Corneal Lesions Caused by Sensory Denervation: Pharmacological Pupil Tests, read before the 145th Meeting, Netherlands Ophthalmological Society , Ophthalmologica 143:103, 1962.Crossref 7. Duke-Elder, W. S.: Text-Book of Ophthalmology , Vol. 2, London, Henry Kimpton, 1943. 8. Fischer, F. P.: Über die Darstellung der Hornhautoberfläche und ihrer Veränderungen im Reflexbild , Arch. Augenheilk. 98:1, 1928. 9. Fischer, F. P.: Der Wasserhaushalt des Auges und seiner Teile , Docum. Ophthal. 1:79, 1938.Crossref 10. Fischer, F. P.: Filme und Phasengrenzen im Auge , Ophthalmologica 118:335, 1949.Crossref 11. Fuchs, E.: Über Dellen in der Hornhaut , Arch. Ophthal. (Leipzig) 78:82, 1911. 12. Fuchs, E.: Lehrbuch der Augenheilkunde , Leipzig and Wien, Franz Deuticke, 1921. 13. Gaule, J.: Der Einfluss des Trigeminus auf die Hornhaut , Zbl. Physiol. 5:409, 1891. 14. Gifford, S. R.; Puntenney, I., and Bellows, J.: Keratoconjunctivitis Sicca , Arch. Ophthal. 30: 207, 1943.Crossref 15. Go Ing Hoen: Over de indroging van het hoornvlies, Thesis, Leiden, 1925. 16. Hartmann, E.: Les Conséquences physiologiques et pathologiques de la section du trijumeau chez l'homme , Ann. Oculist. 161:161-185; 241-259; 336-354, 1924. 17. Holm, S.: Keratoconjunctivitis Sicca and the Sicca Syndrome , Acta Ophthal. ( (Supp. 33) ) 1-230, 1949. 18. Jaffe, M.: Neuroparalytic Keratitis , Arch. Ophthal. 20:688, 1938. 19. MacMillan, J. A., and Cone, W.: Prevention and Treatment of Keratitis Neuroparalytica by Closure of the Lacrimal Canaliculi , Arch. Ophthal. 18:352, 1937.Crossref 20. MacMillan, J. A., and Cone, W. V.: Treatment of Neuroparalytic Keratitis by Closure of the Lacrimal Canaliculi , Arch. Ophthal. 19:278, 1938.Crossref 21. Marx, E.: De la Sensibilité et du desséchement de la cornée , Ann. Oculist. 158:774, 1921. 22. Ollendorff, A.: Über die Rolle der Mikroorganismen bei der Entstehung der neuroparalytischen Keratitis , Arch. Ophthal. (Leipzig) 49:455, 1900. 23. Pannabecker, C. L.: Keratitis Neuroparalytica , Arch. Ophthal. 32:456, 1944.Crossref 24. Paton, L.: The Trigeminal and Its Ocular Lesions , Brit. J. Ophthal. 10:305, 1926.Crossref 25. Pillat, A.: Über Präxerosis und Xerosis corneae als selbstständige Krankheitsbilder der Mangelerkrankung des Auges beim Erwachsenen , Graefe Arch. Ophthal. 124:486, 1930.Crossref 26. Rowbotham, G. F.: The Facial Neuralgias , Trans. Ophthal. Soc. U. K. 77:337, 1957. 27. Schieck, F.: Die Erkrankungen der Conjunctiva, Cornea und Sclera , in Kurzes Handbuch der Ophthalmologie , Vol. 4, Berlin, Springer-Verlag, 1931. 28. Sigelman, S., and Friedenwald, J. S.: Mitotic and Wound-Healing Activities of the Corneal Epithelium: Effect of Sensory Denervation , A.M.A. Arch. Ophthal. 52:46, 1954.Crossref 29. Sjögren, H.: Zur Kenntnis der Keratoconjunctivitis sicca , Acta. Ophthal. ( (Supp. 2) ) 1-151, 1933. 30. Tagawa, S.: Über die Beschaffenheit der Hornhautoberfläche nach Trigeminusdurchschneidung , Arch. Augenheilk. 102:231, 1930. 31. Verhoeff, F. H.: The Cause of Keratitis After Gasserian Ganglion Operations , Amer. J. Ophthal. 8:273, 1925. 32. Verhoeff, F. H.: Treatment of Neuroparalytic Keratitis by Closing the Lacrimal Canaliculi , Arch. Ophthal. 18:1024, 1937.Crossref 33. Von Hippel, E.: Zur Aetiologie der Keratitis neuroparalytica , Arch. Ophthal. (Leipzig) 35:217, 1889. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Desiccation of Cornea and Conjunctiva After Sensory Denervation: Significance of Desiccation for Pathogenesis of Neuroparalytic Keratitis

Archives of Ophthalmology , Volume 67 (4) – Apr 1, 1962

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1962.00960020439010
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Abstract

Abstract Sensory denervation of the eye is known to cause, in experimental animals as well as in man, corneal changes which subsequently may or may not develop into the full-blown picture of neuroparalytic keratitis. Numerous hypotheses have been advanced with regard to the pathogenesis of these initial lesions, which are naturally closely related to the respective authors' views as to the cause of neuroparalytic keratitis proper. The lesions which occur in experimental animals have been well described by Gaule,11 after whom they are commonly called "Gaule's Spots." Practically immediately after the gasserian ganglion or the ophthalmic division of the trigeminal nerve of the rabbit has been severed, an iridescent film is seen to spread over the corneal surface. Small, shallow pits develop which subsequently coalesce into a dry depression of the corneal center. By means of reflectography, Tagawa28 found the iridescence of the corneal surface to be caused by References 1. Arch. Ophthal. 64:34-43, 1960Crossref 2. Pharmacological pupil tests in the desensitized eyes reported elsewhere (1960) suggest that these are due to interruption of the trigeminal proper, not of sympathetic fibers. 3. Beetham, W. P.: Filamentary Keratitis , Trans. Amer. Ophthal. Soc. 33:413, 1935. 4. Behr, C.: Über die Grundlagen der Keratitis neuroparalytica: zugleich ein Beitrag zur Keratitis neuroparalytica nach Alkoholinjektionen ins Ganglion Gasseri , Z. Augenheilk. 62:1, 1927. 5. Dandy, W. E.: Trigeminal Neuralgia and Trigeminal Tic Douloureux , in Lewis' Practice of Surgery , Vol. 12, Hagerstown, Md., W. F. Prior Company, Inc., 1955, pp. 167-187. 6. de Haas, E. B. H.: Role of Sympathetic in Pathogenesis of Corneal Lesions Caused by Sensory Denervation: Pharmacological Pupil Tests, read before the 145th Meeting, Netherlands Ophthalmological Society , Ophthalmologica 143:103, 1962.Crossref 7. Duke-Elder, W. S.: Text-Book of Ophthalmology , Vol. 2, London, Henry Kimpton, 1943. 8. Fischer, F. P.: Über die Darstellung der Hornhautoberfläche und ihrer Veränderungen im Reflexbild , Arch. Augenheilk. 98:1, 1928. 9. Fischer, F. P.: Der Wasserhaushalt des Auges und seiner Teile , Docum. Ophthal. 1:79, 1938.Crossref 10. Fischer, F. P.: Filme und Phasengrenzen im Auge , Ophthalmologica 118:335, 1949.Crossref 11. Fuchs, E.: Über Dellen in der Hornhaut , Arch. Ophthal. (Leipzig) 78:82, 1911. 12. Fuchs, E.: Lehrbuch der Augenheilkunde , Leipzig and Wien, Franz Deuticke, 1921. 13. Gaule, J.: Der Einfluss des Trigeminus auf die Hornhaut , Zbl. Physiol. 5:409, 1891. 14. Gifford, S. R.; Puntenney, I., and Bellows, J.: Keratoconjunctivitis Sicca , Arch. Ophthal. 30: 207, 1943.Crossref 15. Go Ing Hoen: Over de indroging van het hoornvlies, Thesis, Leiden, 1925. 16. Hartmann, E.: Les Conséquences physiologiques et pathologiques de la section du trijumeau chez l'homme , Ann. Oculist. 161:161-185; 241-259; 336-354, 1924. 17. Holm, S.: Keratoconjunctivitis Sicca and the Sicca Syndrome , Acta Ophthal. ( (Supp. 33) ) 1-230, 1949. 18. Jaffe, M.: Neuroparalytic Keratitis , Arch. Ophthal. 20:688, 1938. 19. MacMillan, J. A., and Cone, W.: Prevention and Treatment of Keratitis Neuroparalytica by Closure of the Lacrimal Canaliculi , Arch. Ophthal. 18:352, 1937.Crossref 20. MacMillan, J. A., and Cone, W. V.: Treatment of Neuroparalytic Keratitis by Closure of the Lacrimal Canaliculi , Arch. Ophthal. 19:278, 1938.Crossref 21. Marx, E.: De la Sensibilité et du desséchement de la cornée , Ann. Oculist. 158:774, 1921. 22. Ollendorff, A.: Über die Rolle der Mikroorganismen bei der Entstehung der neuroparalytischen Keratitis , Arch. Ophthal. (Leipzig) 49:455, 1900. 23. Pannabecker, C. L.: Keratitis Neuroparalytica , Arch. Ophthal. 32:456, 1944.Crossref 24. Paton, L.: The Trigeminal and Its Ocular Lesions , Brit. J. Ophthal. 10:305, 1926.Crossref 25. Pillat, A.: Über Präxerosis und Xerosis corneae als selbstständige Krankheitsbilder der Mangelerkrankung des Auges beim Erwachsenen , Graefe Arch. Ophthal. 124:486, 1930.Crossref 26. Rowbotham, G. F.: The Facial Neuralgias , Trans. Ophthal. Soc. U. K. 77:337, 1957. 27. Schieck, F.: Die Erkrankungen der Conjunctiva, Cornea und Sclera , in Kurzes Handbuch der Ophthalmologie , Vol. 4, Berlin, Springer-Verlag, 1931. 28. Sigelman, S., and Friedenwald, J. S.: Mitotic and Wound-Healing Activities of the Corneal Epithelium: Effect of Sensory Denervation , A.M.A. Arch. Ophthal. 52:46, 1954.Crossref 29. Sjögren, H.: Zur Kenntnis der Keratoconjunctivitis sicca , Acta. Ophthal. ( (Supp. 2) ) 1-151, 1933. 30. Tagawa, S.: Über die Beschaffenheit der Hornhautoberfläche nach Trigeminusdurchschneidung , Arch. Augenheilk. 102:231, 1930. 31. Verhoeff, F. H.: The Cause of Keratitis After Gasserian Ganglion Operations , Amer. J. Ophthal. 8:273, 1925. 32. Verhoeff, F. H.: Treatment of Neuroparalytic Keratitis by Closing the Lacrimal Canaliculi , Arch. Ophthal. 18:1024, 1937.Crossref 33. Von Hippel, E.: Zur Aetiologie der Keratitis neuroparalytica , Arch. Ophthal. (Leipzig) 35:217, 1889.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Apr 1, 1962

References