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Depression and Risk of Stroke Morbidity and Mortality

Depression and Risk of Stroke Morbidity and Mortality REVIEW CLINICIAN’S CORNER Depression and Risk of Stroke Morbidity and Mortality A Meta-analysis and Systematic Review An Pan, PhD Context Several studies have suggested that depression is associated with an in- Qi Sun, MD, ScD creased risk of stroke; however, the results are inconsistent. Olivia I. Okereke, MD, SM Objective To conduct a systematic review and meta-analysis of prospective studies assessing the association between depression and risk of developing stroke in adults. Kathryn M. Rexrode, MD Data Sources A search of MEDLINE, EMBASE, and PsycINFO databases (to May Frank B. Hu, MD, PhD 2011) was supplemented by manual searches of bibliographies of key retrieved ar- ticles and relevant reviews. TROKE IS A LEADING CAUSE OF death and permanent disabil- Study Selection We included prospective cohort studies that reported risk esti- mates of stroke morbidity or mortality by baseline or updated depression status as- ity, with significant economic sessed by self-reported scales or clinician diagnosis. Slosses due to functional impair- ments. Depression is highly preva- DataExtraction Twoindependentreviewersextracteddataondepressionstatusatbase- line,riskestimatesofstroke,studyquality,andmethodsusedtoassessdepressionandstroke. lent in the general population, and it Hazard ratios (HRs) were pooled using fixed-effect or random-effects models when ap- is estimated that 5.8% of men and 9.5% propriate.Associationsweretestedinsubgroupsrepresentingdifferentparticipantandstudy of women will experience http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Depression and Risk of Stroke Morbidity and Mortality

JAMA , Volume 306 (11) – Sep 21, 2011

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2011.1282
pmid
21934057
Publisher site
See Article on Publisher Site

Abstract

REVIEW CLINICIAN’S CORNER Depression and Risk of Stroke Morbidity and Mortality A Meta-analysis and Systematic Review An Pan, PhD Context Several studies have suggested that depression is associated with an in- Qi Sun, MD, ScD creased risk of stroke; however, the results are inconsistent. Olivia I. Okereke, MD, SM Objective To conduct a systematic review and meta-analysis of prospective studies assessing the association between depression and risk of developing stroke in adults. Kathryn M. Rexrode, MD Data Sources A search of MEDLINE, EMBASE, and PsycINFO databases (to May Frank B. Hu, MD, PhD 2011) was supplemented by manual searches of bibliographies of key retrieved ar- ticles and relevant reviews. TROKE IS A LEADING CAUSE OF death and permanent disabil- Study Selection We included prospective cohort studies that reported risk esti- mates of stroke morbidity or mortality by baseline or updated depression status as- ity, with significant economic sessed by self-reported scales or clinician diagnosis. Slosses due to functional impair- ments. Depression is highly preva- DataExtraction Twoindependentreviewersextracteddataondepressionstatusatbase- line,riskestimatesofstroke,studyquality,andmethodsusedtoassessdepressionandstroke. lent in the general population, and it Hazard ratios (HRs) were pooled using fixed-effect or random-effects models when ap- is estimated that 5.8% of men and 9.5% propriate.Associationsweretestedinsubgroupsrepresentingdifferentparticipantandstudy of women will experience

Journal

JAMAAmerican Medical Association

Published: Sep 21, 2011

References