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Depigmentation of Eyelids After Topically Administered Thiotepa

Depigmentation of Eyelids After Topically Administered Thiotepa Abstract Total depigmentation of the periorbital skin and lashes developed in a Negro patient who had received topically administered thiotepa for treatment of corneal vascularization following penetrating keratoplasty. A patch test applied to the left forearm produced a similar lesion, which on examination by light and electron microscopy showed a total loss of melanin granules in the epidermis. The skin was otherwise normal and showed no sign of inflammation. This was considered to be an idiosyncratic or allergic reaction to the drug. References 1. Arndt, K.A., and Fitzpatrick, B.: Topical Use of Hydroquinone as a Depigmenting Agent , JAMA 194:965-967 ( (Nov 29) ) 1965.Crossref 2. Spencer, M.C.: Topical Use of Hydroquinone for Depigmentation , JAMA 194:962-964 ( (Nov 29) ) 1965.Crossref 3. Snell, R.S.: Monobenzylether of Hydroquinone , Arch Derm 90:63-70 ( (Jan) ) 1964.Crossref 4. Brun, R.: Contribution à l'Etude de la Dépigmentation Expérimentale: Résultats Préliminaires , Dermatologica (Basel) 118:202-207 ( (April-May) ) 1959.Crossref 5. Brun, R.: Zur Experimentellen Depigmentierung , J Soc Cosmetic Chemists 11:571-580 ( (Dec) ) 1960. 6. Sidi, E.; Bourgeois, J.; and Planet, P.: Traitement des Hyperpigmentations par les Dérivés Hydroquinoniques , Presse Med 69:2369-2372 ( (Dec 2) ) 1961. 7. Jacklin, H.N.: Depigmentation of the Eyelids in Eserine Allergy , Amer J Ophthal 59:89-92 ( (Jan) ) 1965. 8. Iijima, S., and Tokunaga, E.: Experimental Study on Guanofuracin Leucoderma , Jap J Derm 63:490-495 ( (Oct) ) 1953. 9. Frenk, E., et al: Selective Action of Mercaptoethylamines in Melanocytes in Mammalian Skin , Arch Derm 97:465-477 ( (April) ) 1968.Crossref 10. Meacham, C.T.: Triethylene Thiophosphoramide in the Prevention of Pterygium Recurrence , Amer J Ophthal 54:751-753 ( (Nov) ) 1962. 11. Foster, J.B.: Thiotepa Drops for Corneal Vascularization: A Clinical Trial , Trans Ophth Soc Aust 24:104-107, 1965. 12. Zehetbauer, G.: Der Einfluss von Triäthylen-Thiophosphoramid auf die Vaskularisation des Horn-hauttransplantates , Wien Med Wschr 118:135-137 ( (Feb) ) 1968. 13. Langham, M.E.: The Inhibition of Corneal Vascularization by Triethylene Thiophosphoramide , Amer J Ophthal 49:1111-1117 ( (May) ) 1960. 14. Tullis, J.L.: Triethylenephosphoramide in Treatment of Disseminated Melanoma , JAMA 166:37-41 ( (Jan 4) ) 1958.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Depigmentation of Eyelids After Topically Administered Thiotepa

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1969.00990020417021
Publisher site
See Article on Publisher Site

Abstract

Abstract Total depigmentation of the periorbital skin and lashes developed in a Negro patient who had received topically administered thiotepa for treatment of corneal vascularization following penetrating keratoplasty. A patch test applied to the left forearm produced a similar lesion, which on examination by light and electron microscopy showed a total loss of melanin granules in the epidermis. The skin was otherwise normal and showed no sign of inflammation. This was considered to be an idiosyncratic or allergic reaction to the drug. References 1. Arndt, K.A., and Fitzpatrick, B.: Topical Use of Hydroquinone as a Depigmenting Agent , JAMA 194:965-967 ( (Nov 29) ) 1965.Crossref 2. Spencer, M.C.: Topical Use of Hydroquinone for Depigmentation , JAMA 194:962-964 ( (Nov 29) ) 1965.Crossref 3. Snell, R.S.: Monobenzylether of Hydroquinone , Arch Derm 90:63-70 ( (Jan) ) 1964.Crossref 4. Brun, R.: Contribution à l'Etude de la Dépigmentation Expérimentale: Résultats Préliminaires , Dermatologica (Basel) 118:202-207 ( (April-May) ) 1959.Crossref 5. Brun, R.: Zur Experimentellen Depigmentierung , J Soc Cosmetic Chemists 11:571-580 ( (Dec) ) 1960. 6. Sidi, E.; Bourgeois, J.; and Planet, P.: Traitement des Hyperpigmentations par les Dérivés Hydroquinoniques , Presse Med 69:2369-2372 ( (Dec 2) ) 1961. 7. Jacklin, H.N.: Depigmentation of the Eyelids in Eserine Allergy , Amer J Ophthal 59:89-92 ( (Jan) ) 1965. 8. Iijima, S., and Tokunaga, E.: Experimental Study on Guanofuracin Leucoderma , Jap J Derm 63:490-495 ( (Oct) ) 1953. 9. Frenk, E., et al: Selective Action of Mercaptoethylamines in Melanocytes in Mammalian Skin , Arch Derm 97:465-477 ( (April) ) 1968.Crossref 10. Meacham, C.T.: Triethylene Thiophosphoramide in the Prevention of Pterygium Recurrence , Amer J Ophthal 54:751-753 ( (Nov) ) 1962. 11. Foster, J.B.: Thiotepa Drops for Corneal Vascularization: A Clinical Trial , Trans Ophth Soc Aust 24:104-107, 1965. 12. Zehetbauer, G.: Der Einfluss von Triäthylen-Thiophosphoramid auf die Vaskularisation des Horn-hauttransplantates , Wien Med Wschr 118:135-137 ( (Feb) ) 1968. 13. Langham, M.E.: The Inhibition of Corneal Vascularization by Triethylene Thiophosphoramide , Amer J Ophthal 49:1111-1117 ( (May) ) 1960. 14. Tullis, J.L.: Triethylenephosphoramide in Treatment of Disseminated Melanoma , JAMA 166:37-41 ( (Jan 4) ) 1958.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Sep 1, 1969

References