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CLINICIAN’S CORNER REVIEW Delivery of Genomic Medicine for Common Chronic Adult Diseases A Systematic Review Maren T. Scheuner, MD, MPH Context The greatest public health benefit of advances in understanding the hu- Pauline Sieverding, MPA, JD, PhD man genome may be realized for common chronic diseases such as cardiovascular dis- ease, diabetes mellitus, and cancer. Attempts to integrate such knowledge into clini- Paul G. Shekelle, MD, PhD cal practice are still in the early stages, and as a result, many questions surround the HE GREATEST PUBLIC HEALTH BEN- current state of this translation. efit of advances in understand- Objective To synthesize current information on genetic health services for common ing the human genome will adult-onset conditions by examining studies that have addressed the outcomes, con- Tlikely occur as genomic medi- sumer information needs, delivery, and challenges in integrating these services. cine expands its focus from rare genetic Data Sources MEDLINE articles published between January 2000 and February 2008. disorders to inclusion of more common Study Selection Original research articles and systematic reviews dealing with com- chronic diseases, such as coronary heart mon chronic adult-onset conditions were reviewed. A total of 3371 citations were re- disease, stroke, diabetes mellitus, and
JAMA – American Medical Association
Published: Mar 19, 2008
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