Abstract This report gives clinical and histological details of nine new examples of Degos' acanthoma (acanthome a cellules claires). This recently described lesion has not been reported previously in the English literature. Most commonly the acanthoma presents as a small, very slow-growing, firm, solitary nodule on the lower limb in late middle-aged persons. All of our patients showed the characteristic histopathology with abrupt epidermal thickening by pale edematous malpighian cells. In addition our ninth patient showed hyperplasia of sweat ducts beneath the acanthoma. In three cases we were able to make certain histochemical observations on unfixed frozen sections. Our findings tend to support the view that this tumor is of epidermal rather than adnexal origin. References 1. Degos, R., et al: Tumeur épidermique d'aspect particulier: Acanthome à cellules claires , Ann Derm Syph 89:361-371, 1962. 2. Woringer, F.: L'Acanthome à cellules claires , Bull Soc Franc Derm 70:232-233, 1963. 3. Delacrétaz, J.: Acanthomes à cellules claires , Dermatologica 129:147-153, 1964.Crossref 4. Duperrat, B., and Mascaro, J.M.: L'acanthome à cellules claires , Ann Derm Syph 92:5-23, 1965. 5. Bazex, A., et al: Acanthome à cellules claires de Degos , Bull Soc Franc Derm Syph 72:183-184, 1965. 6. Kúta, A.: Beitrag zur Ätiopathogenese der Psoriasis Vulgaris , Derm Waschr 148:199-209, 1963. 7. Takeuchi, T., and Kunaki, H.: Histochemical Demonstration of Phosphorylase in Animal Tissue , J Histochem Cytochem 3:153-160, 1955.Crossref 8. Sanderson, K.V., and Ryan, E.A.: The Histochemistry of Eccrine Poroma , Brit J Derm 75:86-88, 1963.Crossref 9. Mascaro, J.M.: Le diagnostic histologique des tumeurs intra-épidermiques constituées par des cellules claires , Bull Soc Franc Derm Syph 71:260-261, 1964. 10. Lever, W.F., and Castleman, B.: Clear Cell Myoepithelioma of the Skin , Amer J Path 28:691-699, 1952. 11. Pinkus, H.: Keratosis Senilis: A Biologic Concept of its Pathogenesis and Diagnosis Based on the Study of Normal Epidermis and 1730 Seborrheic and Senile Keratoses , Amer J Clin Path 29:193-207, 1958. 12. Williams, M.G.: Acanthomata Appearing After Eczema , Brit J Derm 68:268-271, 1956.Crossref
Archives of Dermatology – American Medical Association
Published: Sep 1, 1966
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