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Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit

Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit Opinion EDITORIAL Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit Christina M. J. E. Vandenbroucke-Grauls, MD, PhD; Jos W. M. van der Meer, MD, PhD The study by Wittekamp and colleagues in this issue of sporins), SOD, and a regimen of oral washing with chlorhexi- dine (CHX mouthwash). The rate of ICU-acquired bloodstream JAMA evaluating strategies for decontamination of mechani- cally ventilated patients in the intensive care unit (ICU) fills infections with multidrug resistant gram- negative bacteria an important gap in the evidence regarding these practices. (MDRGNB) was the primary end point and mortality was the Since the first use of selec- secondary end point. The trial involved 8665 patients in 13 ICUs tive decontamination of the in 6 different countries. After a baseline period, the 3 regi- Related article page 2087 digestive tract (SDD) in criti- mens were applied during consecutive time periods of 6 cally ill patients in the 1980s, the effectiveness of this months in random order per ICU. approach to prevent ICU-acquired infections and reduce The authors found that ICU-acquired bloodstream infec- ICU-related mortality has been a continuous source of tion with MDRGNB occurred in 2.1%, 1.8%, 1.5%, and 1.2% http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2018.13764
Publisher site
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Abstract

Opinion EDITORIAL Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit Christina M. J. E. Vandenbroucke-Grauls, MD, PhD; Jos W. M. van der Meer, MD, PhD The study by Wittekamp and colleagues in this issue of sporins), SOD, and a regimen of oral washing with chlorhexi- dine (CHX mouthwash). The rate of ICU-acquired bloodstream JAMA evaluating strategies for decontamination of mechani- cally ventilated patients in the intensive care unit (ICU) fills infections with multidrug resistant gram- negative bacteria an important gap in the evidence regarding these practices. (MDRGNB) was the primary end point and mortality was the Since the first use of selec- secondary end point. The trial involved 8665 patients in 13 ICUs tive decontamination of the in 6 different countries. After a baseline period, the 3 regi- Related article page 2087 digestive tract (SDD) in criti- mens were applied during consecutive time periods of 6 cally ill patients in the 1980s, the effectiveness of this months in random order per ICU. approach to prevent ICU-acquired infections and reduce The authors found that ICU-acquired bloodstream infec- ICU-related mortality has been a continuous source of tion with MDRGNB occurred in 2.1%, 1.8%, 1.5%, and 1.2%

Journal

JAMA – American Medical Association

Published: Nov 27, 2018

References

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