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DEATH FROM HEMORRHAGIC ENCEPHALITIS FOLLOWING TREATMENT WITH SULPHARSPHENAMINE

DEATH FROM HEMORRHAGIC ENCEPHALITIS FOLLOWING TREATMENT WITH SULPHARSPHENAMINE Death from hemorrhagic encephalitis caused by the arsphenamines has been noted from the earliest years of the use of these drugs.1 Globus and Ginsburg2 in 1933 were able to list sixty cases, clinically and pathologically well authenticated, the great majority of which were reported from European clinics. To this number they added fourteen other clinically typical cases which lacked pathologic confirmation. There are reports of three nonfatal cases since then.3 The two cases reported here are the first to be described in infants. REPORT OF CASES Case 1.—S. F., a 5 month old girl, was brought to the Stanford University Hospital on Sept. 10, 1929, because she had been having convulsions of increasing frequency and severity for twelve hours before admission. Three and one-half months previously snuffles, syphilids and a strongly positive Wassermann reaction of the blood had been discovered. At that time the spinal fluid, which http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

DEATH FROM HEMORRHAGIC ENCEPHALITIS FOLLOWING TREATMENT WITH SULPHARSPHENAMINE

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Publisher
American Medical Association
Copyright
Copyright © 1936 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1936.01970150113009
Publisher site
See Article on Publisher Site

Abstract

Death from hemorrhagic encephalitis caused by the arsphenamines has been noted from the earliest years of the use of these drugs.1 Globus and Ginsburg2 in 1933 were able to list sixty cases, clinically and pathologically well authenticated, the great majority of which were reported from European clinics. To this number they added fourteen other clinically typical cases which lacked pathologic confirmation. There are reports of three nonfatal cases since then.3 The two cases reported here are the first to be described in infants. REPORT OF CASES Case 1.—S. F., a 5 month old girl, was brought to the Stanford University Hospital on Sept. 10, 1929, because she had been having convulsions of increasing frequency and severity for twelve hours before admission. Three and one-half months previously snuffles, syphilids and a strongly positive Wassermann reaction of the blood had been discovered. At that time the spinal fluid, which

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Mar 1, 1936

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