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Darier's Disease: Update on an Effective New Therapy

Darier's Disease: Update on an Effective New Therapy Abstract To the Editor.— I was doubly interested in the two articles in the January Archives (1983;119:72-83) on keratosis follicularis, namely, the reproduction of the article by White, describing the condition (originally published in the J Cutan Genitourin Dis 1889;7:201-209), and the "Commentary: Darier-White Disease" by Rand and Baden.James C. White, MD, professor of dermatology at Harvard University, Boston, and Professor Ferdinand Jean Darier, working independently in Paris, described this previously unidentified entity. White's detailed clinical and histopathologic presentation and photographs are worthy of a second presentation almost a century later.The commentary by Rand and Baden brings this rare disease entity up to date with one exception— therapy. They stated that Darier's disease is clearly a disorder of keratinization and that "oral vitamin A has been used with variable success" and that more dramatic improvement has been reported after the administration of the new synthetic retinoids. Unfortunately, however, an References 1. Ames SR: Factors affecting absorption, transport and storage of Vitamin A . Am J Clin Nutr 1969;22:934-935. 2. Ayres S Jr, Mihan R: Keratosis follicularis (Darier's disease): Response to simultaneous administration of vitamins A and E . Arch Dermatol 1972;106:909-910.Crossref 3. Ayres S Jr, Mihan R, Scribner MD: Synergism of vitamins A and E with dermatological applications . CUTIS 1979;23:600-603, 689, 690. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Darier's Disease: Update on an Effective New Therapy

Archives of Dermatology , Volume 119 (9) – Sep 1, 1983

Darier's Disease: Update on an Effective New Therapy

Abstract

Abstract To the Editor.— I was doubly interested in the two articles in the January Archives (1983;119:72-83) on keratosis follicularis, namely, the reproduction of the article by White, describing the condition (originally published in the J Cutan Genitourin Dis 1889;7:201-209), and the "Commentary: Darier-White Disease" by Rand and Baden.James C. White, MD, professor of dermatology at Harvard University, Boston, and Professor Ferdinand Jean Darier, working independently in...
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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650330002003
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— I was doubly interested in the two articles in the January Archives (1983;119:72-83) on keratosis follicularis, namely, the reproduction of the article by White, describing the condition (originally published in the J Cutan Genitourin Dis 1889;7:201-209), and the "Commentary: Darier-White Disease" by Rand and Baden.James C. White, MD, professor of dermatology at Harvard University, Boston, and Professor Ferdinand Jean Darier, working independently in Paris, described this previously unidentified entity. White's detailed clinical and histopathologic presentation and photographs are worthy of a second presentation almost a century later.The commentary by Rand and Baden brings this rare disease entity up to date with one exception— therapy. They stated that Darier's disease is clearly a disorder of keratinization and that "oral vitamin A has been used with variable success" and that more dramatic improvement has been reported after the administration of the new synthetic retinoids. Unfortunately, however, an References 1. Ames SR: Factors affecting absorption, transport and storage of Vitamin A . Am J Clin Nutr 1969;22:934-935. 2. Ayres S Jr, Mihan R: Keratosis follicularis (Darier's disease): Response to simultaneous administration of vitamins A and E . Arch Dermatol 1972;106:909-910.Crossref 3. Ayres S Jr, Mihan R, Scribner MD: Synergism of vitamins A and E with dermatological applications . CUTIS 1979;23:600-603, 689, 690.

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1983

References