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Darier's Disease: An Evaluation of Its Neuropsychiatric Component

Darier's Disease: An Evaluation of Its Neuropsychiatric Component Abstract Among the skin diseases that have been of interest to both dermatology and neuropsychiatry, exclusive of the entities commonly called psychosomatic, are syphilis, adenoma sebaceum, neurofibromatosis, and the Sturge-Weber syndrome.1 We would like to add Darier's disease (keratosis follicularis) to this list. Since brain and epidermal tissue are both derived from ectoderm, some of the intrinsic pathological processes that are not influenced by exogenous factors may involve both organ systems. If the hypothesis has some degree of validity we might then expect to find some organic involvement in the central nervous system in certain dermatological disease states. We reviewed the records at the University of Illinois since 1940 and at the Veterans Administration Hospital, Hines, Ill., since 1950, and found a total of 6 cases of keratosis follicularis proven by biopsy. We were able to study 5 of these patients both dermatologically and psychologically. Report of Cases Case 1.—A References 1. Yakovlev, P. I., and Riley, H. G.: Congenital Ectodermoses (Neurocutaneous Syndromes) in Epileptic Patients , A.M.A. Arch. Neurol. Psychiat. 26:1145, 1931.Crossref 2. White, J. C.: A Case of Keratosis (Ichthyosis) Follicularis , J. Cutan. Dis. 7:210, 201-209, 1889. 3. Darier, J.: De la psorospermose folliculaire vegetante , Ann. Derm. Syph. (Par.) 10:597, 1889. 4. Boeck, C.: Demonstration of a Case of Darier's Disease with Psychological Aberration, Verhandlungen des dritten Kongresses der Nordischen Dermatologischen Gesellschaft, 1916. 5. Wise, F., and Parkhurst, H. J.: Notes on 2 Unusual Cases of Darier's Disease , Arch. Derm. Syph. 2:430, 1920.Crossref 6. Hailey, H., in discussion on Hitch, J. M.; Callaway, J. L.; and Moseley, V.: Familial Darier's Disease (Keratosis Follicularis) , Southern Med. J. 34:578, 1941.Crossref 7. Leitner, Z. A., and Moore, T.: Vitamin A in Darier's Disease , Brit. J. Derm. 60:41, 1948.Crossref 8. Cockayne, E. A.: Inherited Abnormalities of the Skin and Its Appendages , London, Oxford University Press, 1933, p. 394. 9. Smith, H.: Le Facteur psychosomatique en dermatologie , Un. Méd. Canada 80:1399, 1951. 10. Svendsen, I. B., and Albrectsen, B.: The Prevalence of Dyskeratosis Follicularis (Darier's Disease) in Denmark , Acta Dermatovener. (Stockh.) 39:256-269, 1959. 11. Michelson, H., in discussion on Rostenberg, A., and Fox, J. M.: Darier's Disease, Transactions, Chicago Dermatological Society , A.M.A. Arch. Derm. 81:465, 1960. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Darier's Disease: An Evaluation of Its Neuropsychiatric Component

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Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1961.01580150128021
Publisher site
See Article on Publisher Site

Abstract

Abstract Among the skin diseases that have been of interest to both dermatology and neuropsychiatry, exclusive of the entities commonly called psychosomatic, are syphilis, adenoma sebaceum, neurofibromatosis, and the Sturge-Weber syndrome.1 We would like to add Darier's disease (keratosis follicularis) to this list. Since brain and epidermal tissue are both derived from ectoderm, some of the intrinsic pathological processes that are not influenced by exogenous factors may involve both organ systems. If the hypothesis has some degree of validity we might then expect to find some organic involvement in the central nervous system in certain dermatological disease states. We reviewed the records at the University of Illinois since 1940 and at the Veterans Administration Hospital, Hines, Ill., since 1950, and found a total of 6 cases of keratosis follicularis proven by biopsy. We were able to study 5 of these patients both dermatologically and psychologically. Report of Cases Case 1.—A References 1. Yakovlev, P. I., and Riley, H. G.: Congenital Ectodermoses (Neurocutaneous Syndromes) in Epileptic Patients , A.M.A. Arch. Neurol. Psychiat. 26:1145, 1931.Crossref 2. White, J. C.: A Case of Keratosis (Ichthyosis) Follicularis , J. Cutan. Dis. 7:210, 201-209, 1889. 3. Darier, J.: De la psorospermose folliculaire vegetante , Ann. Derm. Syph. (Par.) 10:597, 1889. 4. Boeck, C.: Demonstration of a Case of Darier's Disease with Psychological Aberration, Verhandlungen des dritten Kongresses der Nordischen Dermatologischen Gesellschaft, 1916. 5. Wise, F., and Parkhurst, H. J.: Notes on 2 Unusual Cases of Darier's Disease , Arch. Derm. Syph. 2:430, 1920.Crossref 6. Hailey, H., in discussion on Hitch, J. M.; Callaway, J. L.; and Moseley, V.: Familial Darier's Disease (Keratosis Follicularis) , Southern Med. J. 34:578, 1941.Crossref 7. Leitner, Z. A., and Moore, T.: Vitamin A in Darier's Disease , Brit. J. Derm. 60:41, 1948.Crossref 8. Cockayne, E. A.: Inherited Abnormalities of the Skin and Its Appendages , London, Oxford University Press, 1933, p. 394. 9. Smith, H.: Le Facteur psychosomatique en dermatologie , Un. Méd. Canada 80:1399, 1951. 10. Svendsen, I. B., and Albrectsen, B.: The Prevalence of Dyskeratosis Follicularis (Darier's Disease) in Denmark , Acta Dermatovener. (Stockh.) 39:256-269, 1959. 11. Michelson, H., in discussion on Rostenberg, A., and Fox, J. M.: Darier's Disease, Transactions, Chicago Dermatological Society , A.M.A. Arch. Derm. 81:465, 1960.

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1961

References