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Cytomegalovirus Transmission and Corneal Transplantation

Cytomegalovirus Transmission and Corneal Transplantation Abstract To the Editor. —Transmission of cytomegalovirus (CMV) from infected donors to recipients is a serious concern in the transplantation of bone marrow, kidneys, and other vascularized organs. Because the immune systems of these recipients are severely compromised by cytotoxic drug and systemic steroid therapies, primary or secondary infection with CMV may cause a variety of clinical diseases, such as hepatitis, pneumonitis, and retinitis. Usually, serologic testing of corneal donors and recipients for antibodies to CMV is not performed. However, when presented with a positive serologic test result from a multiple organ donor, the corneal surgeon may feel uncomfortable in accepting a cornea for transplantation into a patient whose serologic CMV status is unknown. In fact, we know of at least two instances in which tissue was refused by a corneal surgeon solely on the basis of a positive CMV test result from the donor. Since seropositivity in the general population References 1. Bennett S, Holland E, Brannian R, et al: The risk of cytomegalovirus transmission by penetrating keratoplasty. Read at the Eye Bank Association of America meetings, Dallas, Nov 7, 1987. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Cytomegalovirus Transmission and Corneal Transplantation

Archives of Ophthalmology , Volume 106 (7) – Jul 1, 1988

Cytomegalovirus Transmission and Corneal Transplantation

Abstract

Abstract To the Editor. —Transmission of cytomegalovirus (CMV) from infected donors to recipients is a serious concern in the transplantation of bone marrow, kidneys, and other vascularized organs. Because the immune systems of these recipients are severely compromised by cytotoxic drug and systemic steroid therapies, primary or secondary infection with CMV may cause a variety of clinical diseases, such as hepatitis, pneumonitis, and retinitis. Usually, serologic testing of corneal...
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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1988.01060140019003
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —Transmission of cytomegalovirus (CMV) from infected donors to recipients is a serious concern in the transplantation of bone marrow, kidneys, and other vascularized organs. Because the immune systems of these recipients are severely compromised by cytotoxic drug and systemic steroid therapies, primary or secondary infection with CMV may cause a variety of clinical diseases, such as hepatitis, pneumonitis, and retinitis. Usually, serologic testing of corneal donors and recipients for antibodies to CMV is not performed. However, when presented with a positive serologic test result from a multiple organ donor, the corneal surgeon may feel uncomfortable in accepting a cornea for transplantation into a patient whose serologic CMV status is unknown. In fact, we know of at least two instances in which tissue was refused by a corneal surgeon solely on the basis of a positive CMV test result from the donor. Since seropositivity in the general population References 1. Bennett S, Holland E, Brannian R, et al: The risk of cytomegalovirus transmission by penetrating keratoplasty. Read at the Eye Bank Association of America meetings, Dallas, Nov 7, 1987.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1988

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