Access the full text.
Sign up today, get DeepDyve free for 14 days.
Abstract For several years prior to 1943, Dr. Papanicolaou and his staff had been investigating a smear cytologic technique for the investigation of cancerous lesions of the vagina, cervix, and uterus. They found early that, because of the amount of blood and mucus in most smears from the vagina, the usual stains were inadequate as the technique stained all the material, so that finding the abnormal cells was difficult. They devised a stain which picked out the nuclei of aberrant cells and left most of the background unstained. All this material was published in a beautifully illustrated monograph entitled Diagnosis of Uterine Cancer by the Vagina Smear.1 Since that time, this technique has been very widely used, and there is a tremendous amount of literature on its application. Some time later, this technique was used in the investigation of pleural effusions, urine, gastric washings, smears from mouth and throat, bronchi, References 1. Papanicolaou, G. N., and Traut, H. F.: Diagnosis of Uterine Cancer by the Vaginal Smear , New York Commonwealth Fund, Oxford University Press, 1943. 2. Hitch, J. M.; Wilson, T. B., and Scoggin, A.: Evaluation of Rapid Method of Cytologic Diagnosis in Suspected Skin Cancer , South. M.J. 44: 407-414 ( (May) ) 1951.Crossref 3. Sandler, H. C.; Freund, H. R., and Stahl, S. S.: Exfoliative Cytology Applied to the Detection and Treatment of Head and Neck Cancer , Surgery 46:479-485 ( (Sept.) ) 1959. 4. Sandler, H. C., and Stahl, S. S.: Exfoliative Cytology as a Diagnostic Aid in the Detection of Oral Neoplasms , J. Oral Surg. 16:414-418 ( (Sept.) ) 1958. 5. Quero, R., and Maso, C.: Cytology in Paget's Disease of Nipple , J. Invest. Dermat. 31:307-311 ( (Dec.) ) 1958.Crossref 6. Hopp, E. S.: Cytologic Diagnosis and Prognosis in Carcinoma of the Mouth, Pharynx and Nasopharynx , Laryngoscope 68:1281-1287 (Aug., Pt. (2) ) 1958.Crossref 7. Moore, T. D.: A Simple Technique for the Diagnosis of Non-Lipid Histiocytoses (Letterer-Siwe Disease) , Pediatrics 19:438-445 ( (March) ) 1957.
Archives of Dermatology – American Medical Association
Published: Dec 1, 1960
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.