Abstract • Allergy and chronic Pseudomonas aeruginosa (PA) infection are two factors that possibly affect the clinical severity of cystic fibrosis pulmonary disease, although the role of allergy is controversial. We have examined the effects of these factors on actuarial survival rates in 117 children with cystic fibrosis who were skin tested in 1974 and classified as allergic (A+) or nonallergic (A−) by their reactions to 12 prick tests with common environmental allergens. Patients were also classified according to whether or not they had chronic pulmonary infection with PA in 1974 (PA-positive or PA-negative). Survival rates in A + patients were not significantly different from those in the A− group (percent survival to age 16 years, 67% vs 80%), whereas the PA+ group had significantly worse survival rates than the PA− group (percent survival to age 16 years, 53% vs 84%). There was no significant interaction between allergic skin reactions and either age at onset of chronic PA Infection or subsequent duration of survival. (AJDC 1985;139:669-671) References 1. Warner JO, Taylor BW, Norman AP, et al: Association of cystic fibrosis with allergy . Arch Dis Child 1976;51:507-511.Crossref 2. Silverman M, Hobbs FDR, Gordon IRS, et al: Cystic fibrosis, atopy and airways lability . Arch Dis Child 1978;53:873-877.Crossref 3. Nelson LA, Callerame ML, Schwartz RH: Aspergillosis and atopy in cystic fibrosis . Am Rev Respir Dis 1979;120:863-873. 4. Pitcher-Wilmott RW, Levinsky RJ, Gordon I, et al: Pseudomonas infection, allergy and cystic fibrosis . Arch Dis Child 1982;57:582-586.Crossref 5. Wood RE, Boat TF, Doershuk CF: Cystic fibrosis . Am Rev Respir Dis 1976;113:833-878. 6. Hadlai Hull C, Nie NH: SPSS Update 7-9. New York, McGraw-Hill Book Co, 1981. 7. George L, Norman AP: Life tables for cystic fibrosis . Arch Dis Child 1971;46:139-143.Crossref 8. Wilmott RW, Tyson SL, Dinwiddie R, et al: Survival rates in cystic fibrosis . Arch Dis Child 1983;53:835-836.Crossref 9. Lee ET, Desu MM: A computer program for comparing K samples with right-censored data . Comput Programs Biomed 1972;2:315-321.Crossref 10. Hoiby N, Flensborg EW, Beck B, et al: Pseudomonas aeruginosa infection in cystic fibrosis: Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of cross-immunoelectrophoresis . Eur J Respir Dis 1977;58:65-79. 11. Moss RB, Hsu YP, Lewiston NJ: 125I-Clq-binding and specific antibodies as indicators of pulmonary disease activity in cystic fibrosis . J Pediatr 1981;99:215-222.Crossref 12. Cystic fibrosis and Pseudomonas infection , editorial. Lancet 1983;2:257-258.
American Journal of Diseases of Children – American Medical Association
Published: Jul 1, 1985
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera