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Cystic Fibrosis Survival Rates: The Influences of Allergy and Pseudomonas aeruginosa

Cystic Fibrosis Survival Rates: The Influences of Allergy and Pseudomonas aeruginosa Abstract • Allergy and chronic Pseudomonas aeruginosa (PA) infection are two factors that possibly affect the clinical severity of cystic fibrosis pulmonary disease, although the role of allergy is controversial. We have examined the effects of these factors on actuarial survival rates in 117 children with cystic fibrosis who were skin tested in 1974 and classified as allergic (A+) or nonallergic (A−) by their reactions to 12 prick tests with common environmental allergens. Patients were also classified according to whether or not they had chronic pulmonary infection with PA in 1974 (PA-positive or PA-negative). Survival rates in A + patients were not significantly different from those in the A− group (percent survival to age 16 years, 67% vs 80%), whereas the PA+ group had significantly worse survival rates than the PA− group (percent survival to age 16 years, 53% vs 84%). There was no significant interaction between allergic skin reactions and either age at onset of chronic PA Infection or subsequent duration of survival. (AJDC 1985;139:669-671) References 1. Warner JO, Taylor BW, Norman AP, et al: Association of cystic fibrosis with allergy . Arch Dis Child 1976;51:507-511.Crossref 2. Silverman M, Hobbs FDR, Gordon IRS, et al: Cystic fibrosis, atopy and airways lability . Arch Dis Child 1978;53:873-877.Crossref 3. Nelson LA, Callerame ML, Schwartz RH: Aspergillosis and atopy in cystic fibrosis . Am Rev Respir Dis 1979;120:863-873. 4. Pitcher-Wilmott RW, Levinsky RJ, Gordon I, et al: Pseudomonas infection, allergy and cystic fibrosis . Arch Dis Child 1982;57:582-586.Crossref 5. Wood RE, Boat TF, Doershuk CF: Cystic fibrosis . Am Rev Respir Dis 1976;113:833-878. 6. Hadlai Hull C, Nie NH: SPSS Update 7-9. New York, McGraw-Hill Book Co, 1981. 7. George L, Norman AP: Life tables for cystic fibrosis . Arch Dis Child 1971;46:139-143.Crossref 8. Wilmott RW, Tyson SL, Dinwiddie R, et al: Survival rates in cystic fibrosis . Arch Dis Child 1983;53:835-836.Crossref 9. Lee ET, Desu MM: A computer program for comparing K samples with right-censored data . Comput Programs Biomed 1972;2:315-321.Crossref 10. Hoiby N, Flensborg EW, Beck B, et al: Pseudomonas aeruginosa infection in cystic fibrosis: Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of cross-immunoelectrophoresis . Eur J Respir Dis 1977;58:65-79. 11. Moss RB, Hsu YP, Lewiston NJ: 125I-Clq-binding and specific antibodies as indicators of pulmonary disease activity in cystic fibrosis . J Pediatr 1981;99:215-222.Crossref 12. Cystic fibrosis and Pseudomonas infection , editorial. Lancet 1983;2:257-258. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Cystic Fibrosis Survival Rates: The Influences of Allergy and Pseudomonas aeruginosa

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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1985.02140090031019
Publisher site
See Article on Publisher Site

Abstract

Abstract • Allergy and chronic Pseudomonas aeruginosa (PA) infection are two factors that possibly affect the clinical severity of cystic fibrosis pulmonary disease, although the role of allergy is controversial. We have examined the effects of these factors on actuarial survival rates in 117 children with cystic fibrosis who were skin tested in 1974 and classified as allergic (A+) or nonallergic (A−) by their reactions to 12 prick tests with common environmental allergens. Patients were also classified according to whether or not they had chronic pulmonary infection with PA in 1974 (PA-positive or PA-negative). Survival rates in A + patients were not significantly different from those in the A− group (percent survival to age 16 years, 67% vs 80%), whereas the PA+ group had significantly worse survival rates than the PA− group (percent survival to age 16 years, 53% vs 84%). There was no significant interaction between allergic skin reactions and either age at onset of chronic PA Infection or subsequent duration of survival. (AJDC 1985;139:669-671) References 1. Warner JO, Taylor BW, Norman AP, et al: Association of cystic fibrosis with allergy . Arch Dis Child 1976;51:507-511.Crossref 2. Silverman M, Hobbs FDR, Gordon IRS, et al: Cystic fibrosis, atopy and airways lability . Arch Dis Child 1978;53:873-877.Crossref 3. Nelson LA, Callerame ML, Schwartz RH: Aspergillosis and atopy in cystic fibrosis . Am Rev Respir Dis 1979;120:863-873. 4. Pitcher-Wilmott RW, Levinsky RJ, Gordon I, et al: Pseudomonas infection, allergy and cystic fibrosis . Arch Dis Child 1982;57:582-586.Crossref 5. Wood RE, Boat TF, Doershuk CF: Cystic fibrosis . Am Rev Respir Dis 1976;113:833-878. 6. Hadlai Hull C, Nie NH: SPSS Update 7-9. New York, McGraw-Hill Book Co, 1981. 7. George L, Norman AP: Life tables for cystic fibrosis . Arch Dis Child 1971;46:139-143.Crossref 8. Wilmott RW, Tyson SL, Dinwiddie R, et al: Survival rates in cystic fibrosis . Arch Dis Child 1983;53:835-836.Crossref 9. Lee ET, Desu MM: A computer program for comparing K samples with right-censored data . Comput Programs Biomed 1972;2:315-321.Crossref 10. Hoiby N, Flensborg EW, Beck B, et al: Pseudomonas aeruginosa infection in cystic fibrosis: Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of cross-immunoelectrophoresis . Eur J Respir Dis 1977;58:65-79. 11. Moss RB, Hsu YP, Lewiston NJ: 125I-Clq-binding and specific antibodies as indicators of pulmonary disease activity in cystic fibrosis . J Pediatr 1981;99:215-222.Crossref 12. Cystic fibrosis and Pseudomonas infection , editorial. Lancet 1983;2:257-258.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jul 1, 1985

References

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